Clinical trial · Interventional
Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer
A Multicenter Phase II Trial of Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Neoadjuvant (preoperative) concomitant chemoradiotherapy (CRT) is now considered as a standard treatment of locally advanced rectal adenocarcinomas, which correlates better local control and higher sphincter preservation rate. Nimotuzumab, a humanized monoclonal antibody against epidermal growth factor receptor (EGFR) has been reported to improve the therapeutic effect of radiotherapy in some cancers. This study is a clinical phase II trial designed to evaluate the efficacy of the combination of Nimotuzumab administered concurrently with neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer, and to further investigate its side-effect and toxicity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Locally Advanced Rectal Cancer | Malignant Rectal Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Capecitabine | Drug | Capecitabine | ALIAS |
| Nimotuzumab | Drug | Nimotuzumab | ALIAS |
| Oxaliplatin | Drug | Oxaliplatin | ALIAS |
| Preoperative irradiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Nimotuzumab plus chemoradiotherapy
- interventionNames
- Radiation: Preoperative irradiation
- Drug: Nimotuzumab
- Drug: Oxaliplatin
- Drug: Capecitabine
Primary outcomes (1)
- measure
- Pathology complete remission rate
- timeFrame
- 1 year
- description
- Pathology complete remission rate is the primary outcome measure.
Secondary outcomes (5)
- measure
- tumor regression rate
- timeFrame
- 1 year
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Written informed consent 2. Age:18-75 years 3. Histologically confirmed locally advanced colorectal cancer (adenocarcinoma) 4. The lower edge of the tumors located below 12 cm from the anal verge 5. Karnofsky Performance Scale ≥70 points, Life expectancy ≥ 6 months 6. No prior chemotherapy was used 7. No history of regional radiation treatment inthe pelvic cavity 8. Adequate hematologic function: Hb ≥ 100 g/L , WBC≥3.5×109, ANC ≥ 1.5×109 /L，PLT ≥ 100×109 /L Adequate renal function: Cr ≤ 1.5×ULN, TB≤2.5 × ULN Adequate hepatic function: ALT/AST ≤ 2.5×ULN, Alkaline phosphatase ≤ 2.5×ULN 9. Patients without peripheral neuropathy Exclusion Criteria: 1. Other malignant tumors, except for skin basal cell carcinoma, or cervical carcinoma in situ 2. Rectal cancer patients with concurrent colon cancer 3. Pregnant or lactating women 4. Fertile female patients without using any contraceptives 5. Allergic to cisplatin and fluorouracil 6. Patients with previous peripheral neuropathy 7. Serious complications: myocardial infarction, heart failure (NYHA Classification\>II grade),psychiatric history and severe diabetes 8. Treatment with other anti-cancer therapy(including Chinese herbal medicine) 9. Organ transplant patients
References
Publications (0)
Data not yet available