Clinical trial · Interventional
Impact of Probiotics in Modulation of Intestinal Microbiota
Impact of Probiotics in Modulation of Intestinal Microbiota of Patients Undergoing a Resection Colonic
NCT01895530CI-TRIAL-00011263completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR. The investigators believe that patients who use probiotic preoperative would provide cytokine profile less inflammatory than those of the control group.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Saccharomyces boulardii | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Control group
- description
- Conventional treatment with no probiotic supplementation
- type
- EXPERIMENTAL
- label
- Probiotic group
- description
- The patients received one oral lyophilized yeast capsule, each of which contains 100 mg (0,5 x 109 cfu/g) of Saccharomyces boulardii (Merck S.A., Biocodex, Beauvais, French), once a day. The treatment started at least seven days before surgery and stopped on the operation day.
- interventionNames
- Dietary Supplement: Saccharomyces boulardii
Primary outcomes (1)
- measure
- Difference in gene expression of citokynes
- timeFrame
- 15 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * if he or she were older than 18 years * intended to undergo elective CRC resection at UFMG Hospital Exclusion Criteria: * Patients were excluded if they were not able to receive the probiotics seven days before the operation * if colon resection was not performed due to changes in operation strategy, or if they discontinued probiotic use on their own or * if they removed their consent.
References
Publications (0)
Data not yet available
No reference posted for this study.