Clinical trial · Interventional
Sperm Morphology by High Magnification in Fertility Men
Assessment of Sperm Morphology by High Magnification (x6000) With Interference Contrast Microscopy in Fertile Men.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A new concept for observing the fine morphology of spermatozoa at high magnification (x6000) with an inverted microscope, a numeric camera using differential interference contrast has been developed (1). This technique called Motile Sperm Organellar Morphology Examination allows to see some abnormalities, mainly vacuoles on the head of spermatozoa. These vacuoles appear to be related to sperm DNA damage and to affect embryo developmental potential (2, 3, 4). The application of Motile Sperm Organellar Morphology Examination may represent an improvement in the evaluation of semen quality, with some potential clinical repercussions at the diagnostic/prognostic level. First of all, the investigators need data on fertile men in order to define " normality " of sperm morphology at high magnification. The aim of this study is therefore to better characterize these vacuoles (number, surface, position) in a population of men fertile in order to establish normality criteria.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Fertility | — | UNRESOLVED | — |
| Men | Multiple Endocrine Neoplasia | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Assessment of sperm morphology (contrast microscopy). | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Fertile men
- description
- Assessment of sperm morphology by high magnification with interference contrast microscopy.
- interventionNames
- Other: Assessment of sperm morphology (contrast microscopy).
Primary outcomes (1)
- measure
- Mean number of vacuole and mean vacuolar area
- timeFrame
- 1 day
- description
- For each patient, images of 100 spermatozoa was captured the day of the sperm collection
Secondary outcomes (1)
- measure
- Composite outcome measure: Vacuole localization, Semen volume, sperm count, motility, vitality, percentage of normal forms.
- timeFrame
- 1 day
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
INCLUSION CRITERIA: * Age : between 18 and 45 years * Sex : male * Men with proven spontaneous fertility (the pregnancy started less than two years before inclusion) * 2 to 5 days of sexual abstinence * All subjects gave their informed consent to participate in the study * The subjects must be affiliated to a social security scheme. EXCLUSION CRITERIA: * Personal history of infertility * Personal history of chemotherapy * History of recurrent miscarriage in the couple * Andrological history since the last pregnancy: urogenital infection, testicular trauma, testicular torsion, varicocele, abdominopelvic surgery * Fever within 3 months before inclusion.
References
Publications (0)
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