Clinical trial · Observational
Right Side of Heart Function After Lung Surgery
The Pulmonary Vascular / Right Ventricular Response to Lung Resection
NCT01892800CI-TRIAL-00022166unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is explore the impact of lung cancer surgery on the function of the right side of the heart.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Ventricular Failure, Right | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lung resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Study population - lung resection
- description
- Patients with suspected lung cancer undergoing lung resection by anatomic lobectomy
- interventionNames
- Procedure: Lung resection
Primary outcomes (1)
- measure
- Right ventricular ejection fraction
- timeFrame
- 3 days
- description
- The primary objective of this study is determine whether RVEF falls post-operatively in patients undergoing lung resection. The primary outcome is RVEF at 3 days post-lung resection compared to pre-operative values determined by CMR.
Secondary outcomes (4)
- measure
- Association between RVEF and contractility / loading indices
- timeFrame
- 3 days
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: 1. Provision of informed consent 2. Age \>16 years 3. Planned elective lung resection by lobectomy Exclusion Criteria: 1. Pregnancy 2. On-going participation in any investigational research which could undermine the scientific basis of the study 3. Contraindications to magnetic resonance imaging: i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in an part of the body 4. Wedge / segmental / sub-lobar lung resection 5. Pneumonectomy 6. Isolated right middle lobectomy
References
Publications (2)
- DERIVEDGlass A, McCall P, Arthur A, Mangion K, Shelley B. Pulmonary artery wave reflection and right ventricular function after lung resection. Br J Anaesth. 2023 Jan;130(1):e128-e136. doi: 10.1016/j.bja.2022.07.052. Epub 2022 Sep 15. PMID 36115714
- DERIVEDYoung DJ, McCall PJ, Kirk A, Macfie A, Kinsella J, Shelley BG. B-type natriuretic peptide predicts deterioration in functional capacity following lung resection. Interact Cardiovasc Thorac Surg. 2019 Jun 1;28(6):945-952. doi: 10.1093/icvts/ivz016. PMID 30753496