Monosialoganglioside(GM1) Preventing Neurotoxicity Induced by Cisplatin Contained Chemotherapy in NSCLC Patients

Inclusion Criteria:

* Cytological and histological confirmation of non-small cell lung cancer (NSCLC) diagnosis, single sputum cytology diagnosis is not accepted
* Expected survival period is more than 3 months
* Enough blood function reservation: absolute neutrophil count (ANC) 2 x 10E9/L or higher;platelet count 100 x 109 /L or higher;hemoglobin 9 g/dL or higher.
* Enough liver function reservation:the total bilirubin less than upper limit of normal;AST and ALT acuities were less than 2.5 times the upper limit of normal (ULN);Alkaline phosphatase 5 times the upper limit of normal (ULN) or less.
* Clinical doctors identify patients suitable for standard doses of ganglioside drug therapy, and expected time of medication is at least six weeks
* Within 4 weeks before treatment, did not receive other adverse reaction of drugs may cause similar neurotoxicity; 18 weeks before, did not received platinum-based drugs chemical treatment.
* No more than 1 degree of the peripheral nervous system diseases exists before enrollment, also no other symptom or disease could affect the adverse reactions of neurotoxicity pathological.
* Can't accept other adverse reactions may prevent neurotoxicity treatment or care after enrollment.
* Sign the informed consent form.

Exclusion Criteria:

* Patients with poor general condition, PS score more than 2 points
* Women in pregnancy or lactation
* Patients (male or female) have fertility possibility but not willing to or not to adopt effective contraception
* With other neurological dysfunction which can cause inaccurate record of the occurrence of neurotoxicity and severity
* Known or assignment of any of these products to test drugs allergic agent composition
* Doctors think inappropriate for patients with ganglioside medication or estimated time of less than 6 weeks
* Active infection (determined by the researcher)
* According to the researcher's judgment, there is serious disease to endanger the safety of patients, or may prevent the patients from completing the study
* Have a clear history of neurological or psychiatric disorders, including epilepsy or dementia