Study of Additive Omega-3 Fish Oil to Palliative Chemotherapy to Treat Oesophagogastric Cancer

Inclusion Criteria:

* Histologically confirmed gastric or oesophageal carcinoma (irrespective of subtype), deemed incurable as a result of standard staging investigations.
* Measurable disease according to RECIST v1.1 criteria on CT within 4 weeks of study entry
* World Health Organization Performance status 0-2
* Aged \>18 years
* Able to give informed written consent
* Life expectancy \>12 weeks
* Adequate hepatic and renal function documented within 7 days prior to treatment (estimated glomerular filtration rate\>50ml/min, serum bilirubin \< 1.5x upper limit of normal; Alanine transaminase or aspartate transaminase \< 2.5x upper limit of normal; Alkaline phosphatase\< 3x upper limit of normal (in the absence of liver metastases). If liver metastases are present, serum transaminases \< 5x upper limit of normal are permitted.)
* Adequate bone marrow function documented within 7 days (haemoglobin ≥9g/dL, platelets ≥100,000cells/mm3, neutrophil count ≥1500cells/mm3)
* Women of childbearing age must have a negative pregnancy test (urine or serum) at commencement of treatment
* Willing to use contraception if applicable
* Willingness to comply with scheduled visits, treatment, laboratory test, and other aspects of the trial

Exclusion Criteria:

* Prior radical treatment within 6 months of relapse
* Prior treatment with any systemic chemotherapy for metastatic disease
* Prior adjuvant radio- or chemotherapy within 4 weeks of starting the study
* Patients with locally advanced disease deemed suitable for radical chemo-radiotherapy
* Known hyperlipidaemic state
* Hypersensitivity to fish- or egg protein or to any of the active substances or constituents in the lipid emulsion
* Patients with known coagulation disorders
* Any general contra-indications to infusion therapy - pulmonary oedema, hyperhydration, decompensated cardiac insufficiency
* Any unstable medical conditions - uncontrolled diabetes mellitus, acute myocardial infarction, stroke, embolic disease, metabolic acidosis, sepsis, pancreatitis
* Known HIV or hepatitis B or C carrier
* Dementia or significantly altered mental status that would prohibit the understanding or rendering of informed consent and compliance with requirements of the protocol
* History of malignancy other than gastric or oesophageal cancer, with the exception of curative treatment for skin cancer (other than melanoma) or in situ breast or cervical carcinoma, or those treated with curative intent for any other cancer with no evidence of disease for 5 years
* Major surgical procedure or significant traumatic injury within 4 weeks of treatment
* Cerebral metastases
* History of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest CT scan
* Known peripheral neuropathy \> Grade 1 (absence of deep tendon reflexes as the sole neurological abnormality does not render the patient ineligible).
* Lack of physical integrity of the upper gastro-intestinal tract, malabsorption syndrome, or inability to take oral medication (administration of capecitabine by naso-gastric or jejunostomy feeding tube is permitted).