Clinical trial · Interventional
Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence
Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
* Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF) leak, CSF collection and wound dehiscence. * Sample size: 144 * intervention groups: * Group A: Acetazolamide administration for 10 days * Group B: prone positioning for 10 days * Group C: Acetazolamide administration and prone positioning for 10 days * Group D: no intervention * Period of study: Autumn 2012 to the end of winter of 2015
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dermal Sinus | — | UNRESOLVED | — |
| Fibrolipoma of Filum Terminale | — | UNRESOLVED | — |
| Lipomyelomeningocele | — | UNRESOLVED | — |
| Split Cord Malformation | — | UNRESOLVED | — |
| Tethered Cord Syndrome | — | UNRESOLVED | — |
| Tumor | Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acetazolamide | Drug | — | UNRESOLVED |
| Acetazolamide+ prone positioning | Other | — | UNRESOLVED |
| prone positioning | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Acetazolamide
- description
- administration of Acetazolamide for 10 days following the surgery
- interventionNames
- Drug: Acetazolamide
- type
- NO_INTERVENTION
- label
- Control
- description
- control group without any intervention
- type
- EXPERIMENTAL
- label
- Prone positioning
- description
- Positioning the patient following surgery for 10 days
- interventionNames
- Other: prone positioning
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Untethering surgery for primary tethered cord caused by thick filum * Lipomyelomeningocele * Split cord malformation management * Untethering surgery in uncomplicated Dermal sinus * Tumors needing intradural management in lumbosacral region * Having any other disease with similar management technique Exclusion Criteria: * Infected dermoid tumors * Intramedullary abscess * Myelomeningocele surgery and related reoperation * Meningocele * Presence of hydrocephalus
References
Publications (2)
- BACKGROUNDChern JJ, Tubbs RS, Patel AJ, Gordon AS, Bandt SK, Smyth MD, Jea A, Oakes WJ. Preventing cerebrospinal fluid leak following transection of a tight filum terminale. J Neurosurg Pediatr. 2011 Jul;8(1):35-8. doi: 10.3171/2011.4.PEDS10502. PMID 21721886
- DERIVEDShahjouei S, Hanaei S, Habibi Z, Hoseini M, Ansari S, Nejat F. Randomized clinical trial of acetazolamide administration and/or prone positioning in mitigating wound complications following untethering surgeries. J Neurosurg Pediatr. 2016 Jun;17(6):659-66. doi: 10.3171/2015.8.PEDS15393. Epub 2016 Jan 29. PMID 26824595