Clinical trial · Interventional
Optimizing the Use of Entonox® During Screening Colonoscopy
Optimizing the Use of Entonox® During Screening Colonoscopy: an Open Randomised Controlled Trial
NCT01865721CI-TRIAL-00040759completedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will randomise patients undergoing screening colonoscopy to receive Entonox either continuously or as required. Both these methods are used in the published studies of Entonox and in clinical practice. Null hypothesis There will be no difference in pain levels between these two methods of Entonox administration
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Bowel Cancer Screening | — | UNRESOLVED | — |
| Colonoscopy | — | UNRESOLVED | — |
| Entonox | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Entonox | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Continuous administration of Entonox
- description
- Patients randomized to this arm will be asked to inhale Entonox throughout the insertion phase of colonoscopy
- interventionNames
- Drug: Entonox
- type
- ACTIVE_COMPARATOR
- label
- As required administration of Entonox
- description
- Patients randomised to this arm will be asked to use Entonox if and when they have pain
- interventionNames
- Drug: Entonox
Primary outcomes (1)
- measure
- Pain scores
- timeFrame
- Day 1: Prior to discharge from endoscopy department
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Having a bowel cancer screening programme colonoscopy Exclusion Criteria: * Contraindications to Entonox * Previous bowel resections
References
Publications (1)
- DERIVEDBall AJ, Din S, Donnelly M, Riley SA. A randomized controlled trial comparing continuous and as-required nitrous oxide use during screening colonoscopy. Eur J Gastroenterol Hepatol. 2015 Mar;27(3):271-8. doi: 10.1097/MEG.0000000000000281. PMID 25629571