Clinical trial · Interventional
Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients
Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients Who Were 75 Years Old or Over
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Elderly patients have poorer preoperative conditions than younger patients. Therefore, minimally invasive surgery should be an effective treatment method for elderly patients. The investigators conducted a randomized trial that compared laparoscopic surgery and conventional open surgery in elderly patients who were 75 years old or over. The purpose of the present study was to clarify the effect of laparoscopic surgery in elderly patients. In our hypothesis of this trial, laparoscopic surgery is superior to conventional open surgery in short-term results, and same outcome in long -term results. Therefore, laparoscopic surgery would be recommended as standard procedure in an elderly colorectal patient.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic surgery | Procedure | — | UNRESOLVED |
| Open surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Open surgery
- description
- Conventional procedure
- interventionNames
- Procedure: Open surgery
- type
- EXPERIMENTAL
- label
- Laparoscopic surgery
- description
- Minimum invasive procedure
- interventionNames
- Procedure: Laparoscopic surgery
Primary outcomes (1)
- measure
- Early complication rate
- timeFrame
- 30 days after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Age of 75 years old or over * Histologically proven adenocarcinoma * Clinical tumor penetrates visceral peritoneum (T4a), no metastasis (M0) or lower T factor * Elective operation * Tolerable surgery under general anesthesia * No bulky tumor larger than 8cm in diameter * No history of laparotomy for colorectal resection except appendectomy * Provided written informed consent Exclusion Criteria: * Synchronous or metachronous (within 5 years) malignancy in another organ except carcinoma in situ * Multiple colorectal cancer that needs reconstruction two or more times * Acute intestinal obstruction or perforation due to colorectal cancer * Lower rectal cancer that required pelvic side wall lymphadenectomy * Pregnant or lactating women
References
Publications (1)
- DERIVEDIshibe A, Ota M, Fujii S, Suwa Y, Suzuki S, Suwa H, Momiyama M, Watanabe J, Watanabe K, Taguri M, Kunisaki C, Endo I. Midterm follow-up of a randomized trial of open surgery versus laparoscopic surgery in elderly patients with colorectal cancer. Surg Endosc. 2017 Oct;31(10):3890-3897. doi: 10.1007/s00464-017-5418-z. Epub 2017 Feb 15. PMID 28205033