Clinical trial · Interventional
Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients
Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Transverse and Descending Colon Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The long-term results of several large-scale prospective randomized trials that compared laparoscopic-assisted and open colectomy for colon cancer were published in the past decade. The oncologic outcomes were nearly similar in patients who underwent laparoscopic or open surgery. In Japan, the Japan Clinical Oncology Group (JCOG) conducted a randomized trial to compare oncological outcomes between patients who underwent laparoscopic or open surgery for advanced colon cancer and recto-sigmoid cancer. However, the exclusion criterion were concerning tumor site in transverse and descending colon. The reason of exclusion was that laparoscopic procedure was difficult in transverse and descending colon cancers. However, laparoscopic surgery for transverse and descending colon cancer was performed clinically. We conducted a randomized trial that compared laparoscopic surgery and conventional open surgery in in transverse and descending colon cancer. The purpose of the present study was to clarify the safety and feasibility of laparoscopic surgery on in transverse and descending colon cancer patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Neoplasm of Descending Colon | — | UNRESOLVED | — |
| Malignant Neoplasm of Transverse Colon | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic surgery | Procedure | — | UNRESOLVED |
| Open surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Open surgery
- description
- Open colectomy
- interventionNames
- Procedure: Open surgery
- type
- EXPERIMENTAL
- label
- Laparoscopic surgery
- description
- Laparoscopic colectomy
- interventionNames
- Procedure: Laparoscopic surgery
Primary outcomes (1)
- measure
- Early complication rate
- timeFrame
- within the first 30 days after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Age of 20 years old or over * Histologically proven adenocarcinoma * Clinical tumor penetrates visceral peritoneum (T4a), no metastasis (M0) or lower T factor * Elective operation * Tolerable surgery under general anesthesia * No bulky tumor larger than 8cm in diameter * No history of laparotomy for colorectal resection except appendectomy * Provided written informed consent Exclusion Criteria: * Synchronous or metachronous (within 5 years) malignancy in another organ except carcinoma in situ * Multiple colorectal cancer that needs reconstruction two or more times * Acute intestinal obstruction or perforation due to colorectal cancer * Lower rectal cancer that required pelvic side wall lymphadenectomy * Pregnant or lactating women
References
Publications (1)
- DERIVEDToritani K, Watanabe J, Nakagawa K, Suwa Y, Suwa H, Ishibe A, Ota M, Fujii S, Kunisaki C, Endo I. Randomized controlled trial to evaluate laparoscopic versus open surgery in transverse and descending colon cancer patients. Int J Colorectal Dis. 2019 Jul;34(7):1211-1220. doi: 10.1007/s00384-019-03305-2. Epub 2019 May 17. PMID 31102008