Clinical trial · Interventional
Randomized Controlled Trial to Evaluate High Tie Versus Low Tie of the Inferior Mesenteric Artery in Anterior Resection
Randomized Controlled Trial to Evaluate High Tie Versus Low Tie of the Inferior Mesenteric Artery in Rectal Anterior Resection for Rectal Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The tying at a radix of the inferior mesenteric artery (IMA) is recognized as radical cure technique in a rectal cancer surgery in Japan. In one side, the preserving the left colic artery (LCA) that is the technique to maintain blood flow of proximal sigmoid colon is performed in practice. However, there is no evidence that shows effectiveness of this technique. We conducted a randomized trial that compared between high tie and low tie of the IMA in rectal anterior resection to define an appropriate portion of IMA tying.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Rectal Resection | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High tie of IMA | Procedure | — | UNRESOLVED |
| Low tie of IMA | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- High tie of IMA
- description
- In High tie group, IMA was transected at its origin from the abdominal aorta.
- interventionNames
- Procedure: High tie of IMA
- type
- EXPERIMENTAL
- label
- Low tie of IMA
- description
- In the low tie of the IMA, IMA was separated after branching to the left colic artery. The lymph node dissection around the IMA at its origin was performed.
- interventionNames
- Procedure: Low tie of IMA
Primary outcomes (1)
- measure
- Anastomotic leakage rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Age of 20 years old or over * Anterior resection is scheduled for rectal cancer and rectosigmoid cancer preoperatively. * Histologically proven adenocarcinoma * Clinical tumor penetrates visceral peritoneum (T4a), no metastasis (M0) or lower T factor * Elective operation * Tolerable surgery under general anesthesia * No history of laparotomy for colorectal resection except appendectomy * Provided written informed consent Exclusion Criteria: * Synchronous or metachronous (within 5 years) malignancy in another organ except carcinoma in situ * Multiple colorectal cancer that needs reconstruction two or more times * Acute intestinal obstruction or perforation due to rectal cancer * Pregnant or lactating women
References
Publications (1)
- DERIVEDFujii S, Ishibe A, Ota M, Watanabe K, Watanabe J, Kunisaki C, Endo I. Randomized clinical trial of high versus low inferior mesenteric artery ligation during anterior resection for rectal cancer. BJS Open. 2018 Jun 8;2(4):195-202. doi: 10.1002/bjs5.71. eCollection 2018 Aug. PMID 30079388