Clinical trial · Interventional
Adaptive Radiation Therapy for Head & Neck Cancer Patients
Kilovoltage Conebeam Imaging Based Adaptive Radiation Therapy for Head & Neck Patients Treated With Intensity Modulated Radiation Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the utility of kilovoltage (kV) cone beam CT imaging to track the dose delivered in head and neck cancer patients, to assess the benefit of cone beam CT to patients set-up for radiation treatment, to determine how shifts based on kV cone beam CT compare to the standard approach (orthogonal pair), and to develop remote access tools (preferably internet-based) so that the MD can approve these plans in real time.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of Head and Neck | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| concurrent chemo + IGRT | Radiation | — | UNRESOLVED |
| neoadjuvant chemo + IGRT | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- definitive radiation + concomitant chemo
- description
- Concurrent chemo + IGRT: These patients will have chemotherapy during the time of radiation treatment
- interventionNames
- Radiation: concurrent chemo + IGRT
- type
- EXPERIMENTAL
- label
- neoadjuvant chemo
- description
- Neoadjuvant chemo + IGRT: These patients will have chemotherapy prior to other radiation treatment.
- interventionNames
- Radiation: neoadjuvant chemo + IGRT
Primary outcomes (1)
- measure
- Clinical patient response
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients should have an ECOG (Eastern Clinical Oncology Group) performance status of 0-2 * Patients should meet at least one of the following criteria: 1. Locally advanced cancer (T3-T4 and/or N2-N3) 2. Tumors wrapping around critical structures such as the optic nerves, optic chiasm, or brainstem 3. Significant expected weight loss. Exclusion Criteria: * Previous surgical procedure more significant than a biopsy to the primary tumor or regional lymph nodes. * Poor renal function (inability to undergo a CT with IV contrast) * Previous radiation therapy to the head and neck. * Inability to tolerate prolonged immobilization. * Children and women who are pregnant or decline to use contraception.
References
Publications (0)
Data not yet available