Clinical trial · Interventional
Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
A Phase I/II Study of Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain
NCT01846429CI-TRIAL-00018142terminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Drugs unavailable. Study did not progress to Phase 2.
Summary
Brief summary (as posted)
The purpose of this study is to: * Determine how well people tolerate sodium bicarbonate taken by mouth in higher doses than those usually given for heartburn. * Determine if sodium bicarbonate can reduce cancer-related pain.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Hematologic Malignancy | Hematopoietic and Lymphoid Cell Neoplasm | ALIAS | 0.90 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Malignant Solid Tumor | Malignant Solid Neoplasm | CURATED_BROADER | 0.80 |
| Multiple Myeloma | Multiple Myeloma | CURATED_EXACT | 0.92 |
| Neoplasm Metastasis | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
| Tumor | Neoplasm | ALIAS | 0.90 |
| Unresectable Malignant Neoplasm | Malignant Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Sodium Bicarbonate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Sodium Bicarbonate Treatment
- description
- A 3+3 design for Phase I component and a two staged design for Phase II were to be used. Treatment: Sodium Bicarbonate Capsules (900 mg).
- interventionNames
- Drug: Sodium Bicarbonate
Primary outcomes (2)
- measure
- Phase I - Maximum Tolerated Dose (MTD)
- timeFrame
- 4 weeks per participant
- description
- To evaluate the safety (Phase I) of oral Sodium bicarbonate capsules as an adjuvant pain reliever in patients with tumor related moderate to severe pain. To determine the maximum tolerated dose (MTD) of oral sodium bicarbonate capsules for patients with tumor related moderate to severe pain.
- measure
- Phase II - Percent of Participants With Desired Response
- timeFrame
- 4 weeks per participant
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients must have metastatic or unresectable solid malignancy or hematologic malignancy (multiple myeloma or lymphoma) and must have moderate to severe tumor related pain visual assessment scale (VAS)\>4) on a stable or no opioid regimen (at least 3 days of an opiate regimen). VAS score should be greater than 4 at screening to be eligible. * No planned palliative surgery, palliative radiotherapy for at least 4 weeks. However prior radiotherapy, and surgery is allowed and not limited to the number of procedures and courses. Concomitant chemotherapy with agents indicated in protocol guidelines (Tables 10 and 11B, Appendix IV) is allowed. * No evidence of neurologic or psychiatric compromise which in the opinion of the investigator will interfere with completion of study assessments * Age greater than 18 years and able to understand and sign the informed consent document * Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status less than 3. * A female patient and a male patient's female partner, of childbearing potential, must agree to use 2 adequate barrier methods of contraception to prevent pregnancy or to abstain from heterosexual activity throughout the study, starting from Visit 1, while receiving protocol-specified medication, and for 1 month after stopping the medication. Exclusion Criteria: * Patients with neuropathy and/or neuropathic pain as the only pain syndrome are not eligible. * Patients with only chronic non-malignant pain are not eligible. * Patients with renal insufficiency (creatinine \> 2.5mg/dL) are excluded. * Patients with history of congestive heart failure or pulmonary artery hypertension will be excluded. * Patients with uncontrolled hypertension (systolic pressure \>160, diastolic pressure \>100) despite maximal antihypertensive therapy * Patients unable to ingest sodium bicarbonate capsules (such as patients with dysphagia or severe nausea) * Patients with ECOG performance status 3 or higher * Patients with acute leukemia, myelodysplastic syndrome, and chronic myeloid leukemia are not eligible. * Pregnant or lactating patients are not eligible. * Patients with known allergy to sodium bicarbonate or patients with preexisting renal or acid base disorders for which sodium bicarbonate is contraindicated (such as metabolic alkalosis, severe congestive heart failure, hypernatremia, and hypocalcemia (see above)) * Patients with severe ongoing infections which places the patients at increased risks from therapy in the opinion of the investigator * Patients receiving concomitant chemotherapy with agents indicated in protocol guidelines (Tables 10 and 11B, Appendix IV) or target therapy intended to prolong life within 2 weeks of starting the study drug * Patients receiving experimental therapy within 2 weeks of starting study treatment
References
Publications (1)
- DERIVEDGillies RJ, Ibrahim-Hashim A, Ordway B, Gatenby RA. Back to basic: Trials and tribulations of alkalizing agents in cancer. Front Oncol. 2022 Nov 14;12:981718. doi: 10.3389/fonc.2022.981718. eCollection 2022. PMID 36452492