Clinical trial · Interventional
Method of Endogenous TSH Stimulation in the Follow-up of Differentiated Thyroid Cancer
NCT01840332CI-TRIAL-00014032completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The treatment of differentiated thyroid cancer (DCT) includes surgery followed by radioiodine treatment. In the follow-up of patients it is necessary to induce TSH elevation to test for cancer recurrence. One of the options is to stop L-thyroxin replacement for several weeks. Current pilot study aims to induce the necessary TSH elevation by decreasing the L-thyroxin dose. The main hypothesis is that necessary TSH stimulation will be achieved during 4-6 weeks in majority of patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| L-thyroxin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- L-thyroxin
- description
- this is one arm study
- interventionNames
- Drug: L-thyroxin
Primary outcomes (1)
- measure
- TSH level at the end of study
- timeFrame
- 4-6 weeks
- description
- The percentage of patients obtaining TSH level at least 30 imU/L at the end of study period. Blood tests will be obtained after 4 weeks. If TSH \> 30 the patient has completed the study. If TSH \< 30 patient will continue for 1 week and blood tests will be obtained after week 5. If TSH \> 30 the patient has completed the study. If TSH \< 30 patient will be monitored during 1 week and blood tests will be obtained after 6 weeks.
Secondary outcomes (1)
- measure
- change in Billewitz index during the study
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Differentiated thyroid cancer * treated by thyroidectomy and at least 1 ablation with 131-I \> 5 months ago * TSH \< 4 imU/L Exclusion Criteria: * Pregnancy * Known metastasis
References
Publications (0)
Data not yet available
No reference posted for this study.