Clinical trial · Interventional
Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma With T1a Stage
Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Enucleation of Renal Cell Carcinoma With T1a Stage : Clinical Outcomes of a Randomised Controlled Trial
NCT01838720CI-TRIAL-00015379unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To evaluate the feasibility and efficiency of zero ischemia laparoscopic radio frequency ablation assisted enucleation of T1a renal cell carcinoma in comparison with the conventional laparoscopic partial nephrectomy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Renal Cell Carcinoma | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
| Zero Ischemia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ischemia | Procedure | — | UNRESOLVED |
| zero ischemia laparoscopic RFA assisted TE | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- zero ischemia laparoscopic RFA assisted TE
- description
- RFA will be performed for 1 to 4 cycles for 4 to 12 minutes each depending on tumor size and depth. The tumor then will be laparoscopic enucleation without hilar clamping.
- interventionNames
- Procedure: zero ischemia laparoscopic RFA assisted TE
- type
- ACTIVE_COMPARATOR
- label
- conventional laparoscopic partial nephrectomy
- description
- Renal hilum will be accurately isolated and then the artery only will be clamped during surgery.
- interventionNames
- Procedure: ischemia
Primary outcomes (1)
- measure
- the absolute change in glomerular filtration rate (GFR) of the affected kidney
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * patients with sporadic, unilateral, newly diagnosed T1a presumed renal cell carcinoma * patients with normal contralateral renal function (differential renal function of \>40% as determined by radionuclide scintigraphy) * patients agreeable to participate in this long-term follow-up study Exclusion Criteria: * patients' aged \>80 years * patients with other renal diseases * patients not able to tolerate the laparoscopic procedure * patients with previous renal surgery or history of any inflammatory conditions of the operative kidney * patients with the renal tumor close to the calyces
References
Publications (1)
- DERIVEDHuang J, Zhang J, Wang Y, Kong W, Xue W, Liu D, Chen Y, Huang Y. Comparing Zero Ischemia Laparoscopic Radio Frequency Ablation Assisted Tumor Enucleation and Laparoscopic Partial Nephrectomy for Clinical T1a Renal Tumor: A Randomized Clinical Trial. J Urol. 2016 Jun;195(6):1677-83. doi: 10.1016/j.juro.2015.12.115. Epub 2016 Feb 22. PMID 26905020