Clinical trial · Observational
Multicentric Retrospective Review of Extracapsular Lymph Node Involvement After Esophagectomy
Can Extracapsular Lymph Node Involvement be a Tool to Fine-tune UICC TNM 7th Edition for Esophageal Carcinoma?
NCT01837173CI-TRIAL-00010106ECLNI-MCunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is well known that lymph node metastasis is one of the most important prognostic factors in oesophageal carcinoma. The investigators want to determine the influence of lymph node characteristics, being either intracapsular or extracapsular, on overall survival after esophagectomy for esophageal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Extracapsular LNI
- description
- Patients with positive lymph nodes that show extracapsular lymph node involvement
- label
- Intracapsular LNI
- description
- Patients with positive lymph nodes that show NO extracapsular lymph node involvement
Primary outcomes (2)
- measure
- Overall survival by LN-status (being ECLNI or ICLNI)
- timeFrame
- 5 yrs from surgery
- description
- according UICC TNM7 pN (pN1-2-3)
- measure
- Cancer-specific survival by LN-status (being ECLNI or ICLNI)
- timeFrame
- 5 yrs from surgery
- description
- according UICC TNM7 pN (pN1-2-3)- censoring non-esophageal cancer related deaths
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adequate lymph node sampling is of paramount importance. (pT1 - min. 10 LN; \>pT2 min. 20 LN resected). At least the following lymph node stations should be examined: perioesophageal distal 1/3 and perigastric LN, left gastric artery, splenic artery, common hepatic artery, subcarinal lymph nodes. Sugical technique (transthoracic, transhiatal or minimal invasive) is less important if the criterium of adequate lymph node sampling is fulfilled but should be mentioned. Exclusion Criteria: * unforeseen organ metastasis * subcardia tumors * histology other than adenocarcinoma or squamous cell carcinoma * Postoperative (inhospital or 30-day) mortality
References
Publications (0)
Data not yet available
No reference posted for this study.