Clinical trial · Interventional
Bronchoscopic Sampling Techniques in Sarcoidosis
Diagnostic Accuracy of Different Bronchoscopic Sampling Techniques in Patients With Mediastinal Lymph Node Enlargement Suspected of Sarcoidosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal lymph node (MLN) sampling. Still, in some diseases routine cytological specimens are considered insufficient and histological sampling is preferred. The aim of the study is to compare the diagnostic accuracy of EBUS-TBNA and two other, more invasive procedures to obtain histological samples from MLN in patients with clinical and radiological features of sarcoidosis. Bronchoscopy with bronchoalveolar lavage (BAL), EBUS-TBNA, EBUS guided transbronchial forceps biopsy (EBUS-TBFB), large bore (19G) histology TBNA as well as endobronchial forceps biopsy will be performed in 90 consecutive patients with mediastinal lymph node enlargement and clinical and radiological features of sarcoidosis. Diagnostic accuracy of each sampling technique will be calculated and compared to other techniques. Diagnostic yield of different technique combinations will also be calculated and the most efficient diagnostic approach will be defined.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphomas | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Mediastinal Lymph Node Enlargement | — | UNRESOLVED | — |
| Sarcoidosis | — | UNRESOLVED | — |
| Tuberculosis | — | UNRESOLVED | — |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bronchoalveolar lavage (BAL) | Procedure | — | UNRESOLVED |
| EBUS guided transbronchial forceps biopsy (EBUS-TBFB) | Procedure | — | UNRESOLVED |
| EBUS guided transbronchial needle aspiration (EBUS-TBNA) | Procedure | — | UNRESOLVED |
| Endobronchial forceps biopsy | Procedure | — | UNRESOLVED |
| large bore (19G) histologic needle biopsy of the mediastinal lymph nodes | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Bronchoscopic lymph node sampling
- description
- Several different sampling techniques will be used in each patient. They include: EBUS guided transbronchial needle aspiration (EBUS-TBNA), EBUS guided transbronchial forceps biopsy (EBUS-TBFB), large bore (19G) histologic needle biopsy of the mediastinal lymph nodes, forceps biopsy of bronchial mucosa in central and peripheral bronchi
- interventionNames
- Procedure: EBUS guided transbronchial forceps biopsy (EBUS-TBFB)
- Procedure: EBUS guided transbronchial needle aspiration (EBUS-TBNA)
- Procedure: large bore (19G) histologic needle biopsy of the mediastinal lymph nodes
- Procedure: Bronchoalveolar lavage (BAL)
- Procedure: Endobronchial forceps biopsy
Primary outcomes (1)
- measure
- Accuracy of different bronchoscopic sampling methods in making the diagnosis of sarcoidosis.
- timeFrame
- Approximately ten days after the procedure, when the results of the cytological and histopathological examination will be available
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * provided informed consent * mediastinal lymph node enlargement that requires bronchoscopy and transbronchial sampling * clinical presentation that might be consistent with sarcoidosis Exclusion Criteria: * age below 18 years * known contraindications for bronchoscopy and/or mediastinal sampling, e.g. coagulation disorders * lung or extrapulmonary tumors with suspicion of malignant mediastinal lymph node involvement
References
Publications (0)
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