Clinical trial · Interventional
Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney. Interruption of renal blood flow via pedicle clamping is often necessary during partial nephrectomy, especially for complex tumors with deep parenchymal invasion. Ischemia-reperfusion injury is a complex process involving several mechanisms including renal vasoconstriction, extensive tubular damage and glomerular injury. The investigators will examine the postoperative renal function of patients who received intraoperative ketorolac and remote ischemic preconditioning during partial nephrectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Renal Cell Carcinoma | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketorolac tromethamine and remote ischemic preconditioning | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Keromin Group
- interventionNames
- Drug: Ketorolac tromethamine and remote ischemic preconditioning
- type
- PLACEBO_COMPARATOR
- label
- Placebo Group
Primary outcomes (1)
- measure
- serum creatinine
- timeFrame
- at baseline, 2 hr, 12hr, 24 hr, 48 hr, 72 hr after clamping release
Secondary outcomes (3)
- measure
- Creatinine clearance
- timeFrame
- at baseline, 2 hr, 12hr, 24 hr, 48 hr, 72 hr after clamping release
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ASA l and ll * age 20-65 * patients undergoing partial nephrectomy Exclusion Criteria: * preoperative liver or renal dysfunction, * coagulopathy, * chronic alcoholism, * hypersensitivity of NSAID, * history of warfarin, * history of gastric ulcer
References
Publications (0)
Data not yet available