Clinical trial · Interventional
Nutrition for Colorectal Cancer Patients and Neutrophil Functions
Effects Of Standard And/Or Glutamine Dipeptide And/Or Omega-3 Fatty Ascid-Supplemented Parenteral Nutrition On Neutrophil Functions, Interleukin-8 Level And Length Of Stay-A Double Blind,Controlled, Randomized Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Hypercatabolism and immune suppression are frequently seen in patients with malignancy. Preoperative nutritional state is an important factor in determining surgical and postoperative complications because the preoperative nutritional status affects the postoperative nutritional state, immunity and inflammatory response. In these patients, standard parenteral nutrition may not be sufficient to maintain the immunity and provide positive or stabilized nitrogen balance. Preoperative and perioperative supplementation with immune-enhancing enteral nutrition has been reported to increase total lymphocytes and T lymphocytes and decrease circulating levels of interleukin 6 and tumor necrosis factor- alfa. There is a report which showed that glutamine dipeptide supplemented parenteral nutrition improved the cellular and humoral immune functions. The investigators aimed to evaluate the effect of postoperative glutamine-dipeptide and/or omega 3 fatty acid supplemented parenteral nutrition on the neutrophil functions and postoperative course of patients with colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Malnutrition | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Standard-Glutamine | Dietary Supplement | — | UNRESOLVED |
| Standard-glutamine-omega 3 | Dietary Supplement | — | UNRESOLVED |
| Standard (Kabiven) | Dietary Supplement | — | UNRESOLVED |
| Standard-Omega 3 fatty acid | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- Control (standard) (Kabiven)
- description
- an isocaloric and iso-nitrogenous standard parenteral nutrition (Kabiven)
- interventionNames
- Dietary Supplement: Standard (Kabiven)
- type
- EXPERIMENTAL
- label
- Standard parenteral-glutamine (S-D)
- description
- alanine-glutamine (aln-gln) (Dipeptiven) supplemented parenteral nutrition (S-D group, n=8),
- interventionNames
- Dietary Supplement: Standard-Glutamine
- type
- EXPERIMENTAL
- label
- Standard-Omega-3 fatty acid (S-O)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Colorectal cancer patients who were included study were between 50 and 70 years old Exclusion Criteria: * preoperatively suffered from serious comorbid chronic disease and received chemotherapy and radiotherapy * immunosuppressive and /or immunomodulator drugs in last 6 months
References
Publications (0)
Data not yet available