Clinical trial · Interventional
Squamous Cell Carcinoma Antigen Analysis at the University Hospital Ostrava
Squamous Cell Carcinoma Antigen as a Marker of Sinonasal Inverted Papilloma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective study aimed to evaluate the usefulness of squamous cell carcinoma antigen (SCCA) as a clinical marker of sinonasal inverted papilloma (IP). The potential benefit of SCCA in the diagnosis of unilateral nasal pathology and as a marker of hidden recurrence was evaluated as well. Blood samples from patients with sinonasal IP were examined to determine serum SCCA levels before surgery, the day after surgery, and every 6 months during follow-up. Preoperative and postoperative levels of SCCA were compared.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nasal Diseases | — | UNRESOLVED | — |
| Nasal Polyps | — | UNRESOLVED | — |
| Papilloma | Papilloma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgical removal of sinonasal papiloma | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Surgical removal of sinonasal papiloma
- description
- The study group consisted of patients following a surgical removal of sinonasal papiloma, in which the SCCA blood levels were assessed in pre-defined intervals.
- interventionNames
- Device: Surgical removal of sinonasal papiloma
Primary outcomes (1)
- measure
- Changes in blood levels of SCCA before and after surgical removal of sinonasal papiloma
- timeFrame
- 1 week
- description
- The levels of SCCA were assessed before and after the surgical procedure.
Secondary outcomes (1)
- measure
- Changes in blood levels of SCCA at six months after surgical removal of sinonasal papiloma
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * at least three-year follow-up following the surgical procedure * signed Informed Consent Exclusion Criteria: * patient lost during follow-up * patients in critical condition (ASA IV)
References
Publications (2)
- BACKGROUNDYasumatsu R, Nakashima T, Kuratomi Y, Hirakawa N, Azuma K, Tomita K, Cataltepe S, Silverman GA, Clayman GL, Komiyama S. Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract. Cancer. 2002 Jan 1;94(1):152-8. doi: 10.1002/cncr.10144. PMID 11815971
- BACKGROUNDFan GK, Imanaka M, Yang B, Takenaka H. Characteristics of nasal inverted papilloma and its malignant transformation: a study of cell proliferation and programmed cell death. Am J Rhinol. 2006 May-Jun;20(3):360-3. doi: 10.2500/ajr.2006.20.2851. PMID 16871944