Clinical trial · Observational
Long-term Follow-up Prognosis of Atrophic Gastritis After 3 Years
Significance of Helicobacter Pylori Infection and Pepsinogen Levels on the Prognosis of Atrophic Gastritis - Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Serum pepsinogen (PG) levels are considered reliable markers for progression of atrophic gastritis with a stepwise reduction in the serum PG I level or PG I/II ratio. A combination of serum PG levels and Helicobacter pylori serology are used as a biomarker strategy for detection of individuals at increased risk of gastric neoplasm based on Correa's hypothesis. The investigators aimed to uncover whether this combination method could predict the risk of gastric neoplasms and the progression of chronic atrophic gastritis after 3 years. All the participants will be followed for an expected average of 3 years.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Adenoma | Gastric Adenoma | ONTOLOGY_EXACT | 0.98 |
| Gastric Atrophy | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Neoplasm | Gastric Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Intestinal Metaplasia | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- atrophy-/Hp- group
- description
- Subjects without Helicobacter pylori infection and without atrophy
- label
- atrophy-/Hp+
- description
- Subjects with Helicobacter pylori infection and without atrophy
- label
- atrophy+/Hp+
- description
- Subjects with Helicobacter pylori infection and with atrophy
- label
- atrophy+/Hp-
- description
- Subjects without Helicobacter pylori infection and with atrophy
Primary outcomes (1)
- measure
- Newly developed gastric neoplasm
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Korean adults older than 18 year-old * Subjects who agreed on serum pepsinogen tests, H. pylori serology, and upper gastrointestinal endoscopy on the same day Exclusion Criteria: * Subjects who had past history of gastric surgery * Abnormal endoscopic or laboratory finding that require further treatment * Any evidence of malignancy other than gastric neoplasm
References
Publications (0)
Data not yet available