Clinical trial · Interventional
Dietary Fat, Eicosanoids and Breast Cancer Risk
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of this investigation is to determine whether diets designed to increase plasma n3 concentrations (a low fat diet, with or without n3 fatty acid enrichment), will favorably affect sex hormone distribution in women in a direction associated with reduced risk of sex hormone-mediated cancer development. Specifically, we hypothesize that an increased concentration of circulating n3 fatty acids will reduce the biochemical markers associated with increased risk for developing certain sex hormone mediated cancers such as breast cancer
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High Fat Diet | Other | — | UNRESOLVED |
| Low Fat diet | Other | — | UNRESOLVED |
| Low Fat high n3 diet | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (6)
- type
- EXPERIMENTAL
- label
- Low Fat, High Fat, Low Fat High Omega 3
- description
- See Intervention Description
- interventionNames
- Other: Low Fat diet
- Other: Low Fat high n3 diet
- Other: High Fat Diet
- type
- EXPERIMENTAL
- label
- Low Fat, Low Fat High Omega 3, High Fat
- description
- See Intervention Description
- interventionNames
- Other: Low Fat diet
- Other: Low Fat high n3 diet
- Other: High Fat Diet
- type
- EXPERIMENTAL
- label
- High Fat, Low Fat, Low Fat High Omega 3
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 40 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Postmenopausal women * 45 to 70 years old, * at least one year since their last menstrual period * not using hormone replacement therapy, * BMI between 19 -29 * willingness to discontinue use of over-the-counter medications with anti-prostaglandin activity such as aspirin or non-steroidal anti-inflammatory medications * consumption of a "Typical " American diet with no unusual dietary practices such as compliance with a strict vegetarian diet * willingness to comply with the demands of the experimental protocol. Exclusion Criteria: * Smoking * Known disease process, and 3) Use of prescription medications, including hormone replacement therapy.
References
Publications (4)
- BACKGROUNDMcColley SP, Georgopoulos A, Young LR, Kurzer MS, Redmon JB, Raatz SK. A high-fat diet and the threonine-encoding allele (Thr54) polymorphism of fatty acid-binding protein 2 reduce plasma triglyceride-rich lipoproteins. Nutr Res. 2011 Jul;31(7):503-8. doi: 10.1016/j.nutres.2011.06.003. PMID 21840466
- BACKGROUNDRaatz SK, Young LR, Picklo MJ Sr, Sauter ER, Qin W, Kurzer MS. Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. Nutr Res. 2012 Jan;32(1):1-7. doi: 10.1016/j.nutres.2011.12.006. PMID 22260857
- BACKGROUNDYoung LR, Raatz SK, Thomas W, Redmon JB, Kurzer MS. Total dietary fat and omega-3 fatty acids have modest effects on urinary sex hormones in postmenopausal women. Nutr Metab (Lond). 2013 Apr 23;10(1):36. doi: 10.1186/1743-7075-10-36. PMID 23618064
- RESULTYoung LR, Kurzer MS, Thomas W, Redmon JB, Raatz SK. Effect of dietary fat and omega-3 fatty acids on urinary eicosanoids and sex hormone concentrations in postmenopausal women: a randomized controlled feeding trial. Nutr Cancer. 2011;63(6):930-9. doi: 10.1080/01635581.2011.589957. Epub 2011 Jul 11. PMID 21745038