Clinical trial · Interventional
Effect of Low-frequency Electroacupuncture (EA) on Polycystic Ovary Syndrome
NCT01812161CI-TRIAL-00031813completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Low-frequency electroacupuncture (EA) can decrease serum 17-hydroxyprogesterone (17-OHP), androstenedione (A) and testosterone (T)of young women with polycystic ovary syndrome in the Human chorionic gonadotrophin (HCG) stimulation test ,also,we hypothesize that EA is more efficiency in improving ovulation rate and menstrual cycle than sham acupuncture.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| acupuncture protocol 1 | Other | — | UNRESOLVED |
| Acupuncture protocol 2 | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Acupuncture protocol 1
- description
- Acupuncture protocol 1:participants will receive treatment (acupuncture protocol 1, real acupuncture) twice a week; each treatment session can be separated by an interval of 2-4 days, with a maximum of 32 treatment sessions during 16 weeks. Each treatment session lasts for 30 minutes.
- interventionNames
- Other: acupuncture protocol 1
- type
- SHAM_COMPARATOR
- label
- Acupuncture protocol 2
- description
- Acupuncture protocol 2:participants will receive treatment (acupuncture protocol 2, sham acupuncture) twice a week; each treatment session can be separated by an interval of 2-4 days, with a maximum of 32 treatment sessions during 16 weeks. Each treatment session lasts for 30 minutes. All participants will receive treatment twice a week; each treatment session can be separated by an interval of 2-4 days, with a maximum of 32 treatment sessions during 16 weeks. Each treatment session lasts for 30 minutes.
- interventionNames
- Other: Acupuncture protocol 2
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 28 Years
Show eligibility criteria text
Inclusion Criteria: * 1\) Unmarried women with age between 18 and 28 years and without bearing requirement within 4 months. * 2\) Confirmed diagnosis of PCOS according to the Rotterdam criteria: Oligomenorrhea(Menstrual cycle\> 35 days, and less than 8 cycles per year), or amenorrhea (Menstrual cycle\> 90 days) and one of the following two criteria; clinical or biochemical hyperandrogenism and/or polycystic ovarian morphology. Exclusion Criteria: * 1\) Patients with hyperprolactinemia. * 2\) Patients with androgens secrete increased abnormal which caused by adrenal or ovarian tumors. * 3\) Patients with uncorrected thyroid disease\[thyroid-stimulating hormone (TSH) \<0.2 milli-International Unit /milliliter(mIU/mL) or \>5.5 mIU/mL\]except the patients with normal TSH in the past 1 year. * 4)Suspected Cushing syndrome patients. * 5)Patients who Received Estrogen, Progesterone or Oral contraceptives Oral contraceptives and hormone medications within the past 1 months. It takes at least one month to Eliminate these medicines, or it will influence the results * 6\) Patients who Received other medications that have influence on Reproductive function. or metabolism within the past 2 months( such as Anti obesity medications,Anti diabetic medications, traditional Chinese medicine and so on). * 7)Patients who took acupuncture treatment within the past 3 months. * 8)Patient who are unwilling to give written consent to the study.
References
Publications (3)
- BACKGROUNDJedel E, Labrie F, Oden A, Holm G, Nilsson L, Janson PO, Lind AK, Ohlsson C, Stener-Victorin E. Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E37-45. doi: 10.1152/ajpendo.00495.2010. Epub 2010 Oct 13. PMID 20943753
- DERIVEDDong HX, Wang Q, Wang Z, Wu XK, Cheng L, Zhou ZM, Yang L, Yi P, Huang DM. Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women: A Randomized Controlled Trial. Chin J Integr Med. 2021 Oct;27(10):737-743. doi: 10.1007/s11655-021-3482-z. Epub 2021 Jul 28. PMID 34319506
- DERIVEDWang Z, Dong H, Wang Q, Zhang L, Wu X, Zhou Z, Yang L, Huang D. Effects of electroacupuncture on anxiety and depression in unmarried patients with polycystic ovarian syndrome: secondary analysis of a pilot randomised controlled trial. Acupunct Med. 2019 Feb;37(1):40-46. doi: 10.1136/acupmed-2017-011615. Epub 2019 Mar 7. PMID 30843421