Clinical trial · Interventional
Ion Irradiation of Sacrococcygeal Chordoma
Hypofractionated Ion Irradiation (Protons or Carbon Ions) of Sacrococcygeal Chordoma
NCT01811394CI-TRIAL-00072002ISACunknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with carbon ions or protons using the raster scan technique.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Sacral Chordoma | Sacral Chordoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| carbon ions | Radiation | — | UNRESOLVED |
| protons | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- protons
- description
- 16x4GyE protons
- interventionNames
- Radiation: protons
- type
- EXPERIMENTAL
- label
- Carbon ions
- description
- 16x4GyE carbon ions
- interventionNames
- Radiation: carbon ions
Primary outcomes (1)
- measure
- safety and feasibility of hypofractionated irradiation in patients with sacrococcygeal chordoma using ions (protons or carbon ions) in raster scan technique
- timeFrame
- From date of treatment start until 12 months after treatment.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Histological confirmation of sacrococcygeal chordoma * Karnofsky performance status ≥ 70% * Patients age 18 - 80 years * Macroscopic tumour (MRI) * Written informed consent Exclusion Criteria: * Lack of macroscopic tumour * Tumor extension in craniocaudal direction \>16cm * Metal implants at the level of the tumor which could influence the treatment planning * Inability of the patient to lie quiet for at least 20 minutes (eg due to pain) * Prior radiotherapy of the pelvic region * Simultaneous participation in another trial that could influence the results of the study * Active medical implants without treatment approval at the time of ion irradiation (eg, cardiac pacemaker, defibrillator)
References
Publications (1)
- BACKGROUNDUhl M, Edler L, Jensen AD, Habl G, Oelmann J, Roder F, Jackel O, Debus J, Herfarth K. Randomized phase II trial of hypofractionated proton versus carbon ion radiation therapy in patients with sacrococcygeal chordoma-the ISAC trial protocol. Radiat Oncol. 2014 Apr 29;9:100. doi: 10.1186/1748-717X-9-100. PMID 24774721