Clinical trial · Observational
Gene Analysis in Studying Susceptibility to Wilms Tumor
A Genome-Wide Association Study in Wilms Tumor
NCT01808079CI-TRIAL-00023586completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial studies gene analysis in studying susceptibility to Wilms tumor. Finding genetic markers for Wilms tumor may help identify patients who are at risk of relapse.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Recurrent Childhood Kidney Neoplasm | Childhood Kidney Neoplasm | CURATED_BROADER | 0.78 |
| Stage III Kidney Wilms Tumor | Kidney Wilms Tumor | CURATED_BROADER | 0.78 |
| Stage II Kidney Wilms Tumor | Kidney Wilms Tumor | CURATED_BROADER | 0.78 |
| Stage I Kidney Wilms Tumor | Kidney Wilms Tumor | CURATED_BROADER | 0.78 |
| Stage IV Kidney Wilms Tumor | Kidney Wilms Tumor | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laboratory Biomarker Analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Ancillary-correlative (genetic markers of Wilms tumor)
- description
- Samples are analyzed for SNP profiling using real-time PCR and MLPA.
- interventionNames
- Other: Laboratory Biomarker Analysis
Primary outcomes (5)
- measure
- Frequencies between cases and controls at each SNP
- timeFrame
- Baseline
- description
- Compared using the Cochran Armitage trend test (1-df). The data will be analyzed individually for the UK/US study populations and combined using a Mantel-Haenszel analysis adjusting for study group, and related methods which allow for different effects in each population (for confirmed loci, we will compare effects across populations).
- measure
- Frequency of maternal and paternal allelic transmission for risk alleles
- timeFrame
- Baseline
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * 3000 samples from the 1958 Birth Cohort (58C) and 3000 from the UK Blood Service control series (NBS)
References
Publications (0)
Data not yet available
No reference posted for this study.