Clinical trial · Interventional
Intraoperative MRI and 5-ALA Guidance to Improve the Extent of Resection in Brain Tumor Surgery
NCT01798771CI-TRIAL-00009563IMAGERunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators hypothesize that the rate of radiologically complete resections of contrast-enhancing brain tumors following surgeries aided by use of 5-ALA induced fluorescence guidance and use of an intraoperative ultra-low field MRI is higher compared to surgeries aided by 5-ALA induced fluorescene alone.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
| Metastasis | — | UNRESOLVED | — |
| Primary Malignant Neoplasm of Nervous System | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Control arm | Procedure | — | UNRESOLVED |
| Interventional arm | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Control arm
- description
- 5-ALA fluorescence guided surgery in patients with contrast enhancing tumors.
- interventionNames
- Procedure: Control arm
- type
- OTHER
- label
- Interventional arm
- description
- 5-ALA fluorescence guided surgery with the additional use of an intraoperative MRI for resection control in patients with contrast enhancing tumors.
- interventionNames
- Procedure: Interventional arm
Primary outcomes (1)
- measure
- Extent of Resection
- timeFrame
- Early postoperative MRI within 72 hrs
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * adult patient (\> 18 years) able to give informed consent * primary supratentorial intra-axial brain tumor exhibiting contrast enhancement suspected to be malignant glioma * tumor must be deemed completely resectable by neurosurgeon * diagnostic MRI Exclusion Criteria: * patient unable or unwilling to give informed consent * infratentorial tumor location * tumor location in or near eloquent areas * multifocal tumor * existance of contraindications to undergo MRI examination * previous surgical treatment for an intraaxial brain tumor
References
Publications (0)
Data not yet available
No reference posted for this study.