A Study of Improving the Efficacy of Treatment in Diffused Large B Cell Lymphoma Patients

Inclusion Criteria:

* Age ≥18 and ≤70 years old.
* Histological documented untreated CD20(+) diffused large B cell lymphoma.
* Measurable disease and evaluable lesion.
* Never previously treated with radiotherapy, chemotherapy or surgery for malignant disease.
* Normal Haematological,liver and kidney function (Neutrophil count ≥ 1.5 × 109/L ,hemoglobin ≥ 100g/L,platelets ≥ 100 × 109/L)
* ECOG Performance status 0-3,Life expectancy of at least 3 months.
* Without history of another malignancy
* Without any conflict serious systemic disease
* Without any accompany treatment(including steroids drugs)
* Subjects must have signed and informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study.
* Female subjects must be practicing and effective methods of birth control for at least 6 months throughout and after study; and have a negative serum β-hCG pregnancy test at screening.

Exclusion Criteria

* Patients with prior clinical study within 3 months.
* Secondary lymphoma induced by chemotherapy or radiotherapy for another malignancy
* Transformed lymphoma
* Primary central nervous system lymphoma or primary testis lymphoma
* History of allergic reaction to any ectogenic proteins
* Prior treatment for lymphoma .
* History of another malignancy
* Neutrophil count \< 1.0× 109/L ,hemoglobin \< 90g/L,platelets \< 90 × 109/L,concurrent treatment with systemic antibiotic or antiviral drug for active infection.
* Decompensated heart failure, dilated cardiomyopathy, coronary artery disease with depression of ST-T for electrocardiogram, myocardial infarction within 6 months
* Serious infective or organic disease
* Kidney dysfunction not related to lymphoma(Creatinine clearance≥ 2× institutional upper limit of normal)
* liver dysfunction not related to lymphoma(transaminase≥3× institutional upper limit of normal,and/or bilirubin≥2.0mg/dl)
* clinical syndrome of encephalon functional disorder,serious psychosis
* female subject who is pregnant or breast-feeding