Clinical trial · Observational
Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk. The presurgical mapping of eloquent areas with functional magnetic resonance imaging (fMRI) is helpful to plan the surgery. BOLD fMRI is now the gold standard to map language areas. However, BOLD signal is diminished near the brain tumor. It is now possible to detect cortical activation with arterial spin labeling (ASL) techniques, detecting variations of perfusion during an activation paradigm (fASL), fASL could be interesting to detect eloquent areas near a brain tumor.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasms | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL)
- timeFrame
- 2 years
- description
- Qualitative and quantitative comparison of brain activations obtained with both techniques (BOLD fMRI and fASL) to presurgically detect language areas located near a brain tumor
Secondary outcomes (2)
- measure
- Langage laterality index obtained with both techniques (BOLD fMRI and fASL)and fASL)
- timeFrame
- 2 years
- description
- Size and location of activations obtained with BOLD fMRI and fASL in the presurgical detection of language areas
- measure
- Difference of cerebral blood flow maps obtained with ASL and fASL
- timeFrame
- 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient 18 years and older * Brain tumor involving frontal and/or temporal lobe and/or insula, with scheduled neurosurgery * Patient able of accepting protocol information * Patient who received information about the protocol and had not expressed its opposition to participate Exclusion Criteria: * Patient with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI * Claustrophobic patient * Patients who cannot cooperate for the fMRI * Patients subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
References
Publications (0)
Data not yet available