Clinical trial · Interventional
Soft Coagulation for the Prevention of Adenoma Recurrence
Soft Coagulation for the Prevention of Adenoma Recurrence After Endoscopic Mucosal Resection (EMR) of Large Sessile Colonic Polyps: A Multicentre, Randomized Trial.
NCT01789749CI-TRIAL-00050835SCARcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recurrence after endoscopic mucosal resection of laterally spreading lesions (LSL) \>= 20mm in size occurs in approximately 20% of cases at surveillance colonoscopy. We aim to evaluate the efficacy of prophylactic adjuvant thermal ablation of the EMR mucosal defect margin in reducing adenoma recurrence following colonic EMR.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colonic Adenomas | Adenoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No Snare Tip Soft Coagulation | Other | — | UNRESOLVED |
| Snare Tip Soft Coagulation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- No Coagulation Arm
- description
- Patients do not receive Snare Tip Soft Coagulation to the edge of the endoscopic resection defect
- interventionNames
- Other: No Snare Tip Soft Coagulation
- type
- EXPERIMENTAL
- label
- Coagulation Arm
- description
- Patients to receive Snare Tip Soft Coagulation to the edge of the endoscopic resection defect
- interventionNames
- Other: Snare Tip Soft Coagulation
Primary outcomes (1)
- measure
- Endoscopic recurrence
- timeFrame
- 4-6 months and 18 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Referred for removal of a colonic polyp \>= 20mm in size * Able to give informed consent to involvement in trial Exclusion Criteria: * Younger than 18 years of age * Highly dependant on medical care * Women who are pregnant or may be pregnant. * Taken clopidogrel within 7 days * Taken warfarin within 5 days * Had full therapeutic dose unfractionated heparin within 6 hours * Had full therapeutic dose low molecular weight heparin (LMWH) within 12 hours * Known clotting disorder * Previous attempt at EMR of the polyp referred for resection * Polyp located at the ileo-caecal valve, appendiceal orifice * Fully circumferential polyp * Incomplete snare resection of the polyp
References
Publications (1)
- DERIVEDKlein A, Tate DJ, Jayasekeran V, Hourigan L, Singh R, Brown G, Bahin FF, Burgess N, Williams SJ, Lee E, Sidhu M, Byth K, Bourke MJ. Thermal Ablation of Mucosal Defect Margins Reduces Adenoma Recurrence After Colonic Endoscopic Mucosal Resection. Gastroenterology. 2019 Feb;156(3):604-613.e3. doi: 10.1053/j.gastro.2018.10.003. Epub 2018 Oct 6. PMID 30296436