Study of Vaccination With Poly-ICLC and Peptide-pulsed Dendritic Cells

Inclusion Criteria:

* Patients must have histologically or cytologically confirmed diagnosis of melanoma that is metastatic and/or unresectable. If the histologic diagnosis is based on a metastatic site, the histology must be compatible with melanoma.
* Patients must be HLA-A2 positivity by serological testing.
* Patients must have measurable disease per RECIST 1.1
* Patients may have had prior cancer therapy. Patients do not need to demonstrate progression to be considered for this trial.
* Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
* Age ≥ 18 years.
* Patient must have an expected life expectancy greater than 3 months.
* Signed, written IRB-approved informed consent.
* Acceptable organ function:
* Bilirubin ≤ 3 times upper limit of normal (CTCAE Grade 2 baseline)
* AST (SGOT), ALT (SGPT) ≤ 3 x ULN (CTCAE Grade 1 baseline)
* Serum creatinine ≤1.5 XULN (CTCAE Grade 1 baseline)
* Acceptable hematologic status:
* Absolute neutrophil count ≥ 1000 cells/mm3,
* Platelet count ≥ 75,000 (plt/mm3), (CTCAE Grade 1 baseline)
* Hemoglobin ≥ 9 g/dL.
* Urinalysis with no clinically significant abnormalities.
* PT and PTT ≤ 1.5 X ULN after correction of nutritional deficiencies that may contribute to prolonged PT/PTT.

Exclusion Criteria:

* Patients must not have any serious uncontrolled acute or chronic medical condition that would interfere with this treatment. Examples would include active acute or chronic infection requiring antibiotics, uncontrolled cardiovascular, endocrine, or infectious disease.
* Patients must not have significant ongoing cardiac problems, myocardial infarction within the last six months, uncontrolled hypertension, unstable angina, uncontrolled arrhythmia or congestive heart failure.
* Surgery less than or equal to 14 days prior to study registration
* Patients who have had prior radiation or chemotherapy in which the last treatment administration is less than or equal to 28 days prior to registration. Patients who have had prior treatment with ipilimumab or Interleukin-2 will be allowed as long as this 28 day wash-out period is followed.
* Patients who are breast feeding or have a positive pregnancy test (if female).
* Patients with active CNS lesions are excluded (i.e., those with radiographically unstable, symptomatic lesions). However, a patient treated with stereotactic therapy or surgery is eligible if the patient remains without evidence of disease progression in the brain and is stable for 1 month. Whole brain radiotherapy is not allowed, with the exception of patients who have had definitive resection or stereotactic therapy of all radiologically detectable parenchymal lesions.
* Patients must have no plans to receive concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy or any other type of therapy for treatment of cancer while on this protocol treatment.
* Due to the undetermined effect of this treatment regimen in patients with HIV-1 infection and the potential for serious interaction with anti-HIV medications, patients known to be infected with HIV are not eligible for this study.
* Due to the possibility of harm to a fetus or nursing infant from this treatment regimen, patients must not be pregnant or nursing. Women and men of reproductive potential must have agreed to use an effective contraceptive method.
* No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years.