Clinical trial · Observational
Changes in Metabolic Status in Patients With Total Thyroidectomy
NCT01781767CI-TRIAL-00009262Thyroid cancerunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Changes in UCP2 mRNA concentrations.
- timeFrame
- Base line (before opporation), 2 weeks after opporation and for after opporation.
- description
- The difference between the result at two weeks and four months compare to base line.
Secondary outcomes (2)
- measure
- Weight
- timeFrame
- Approximately 4 months
- measure
- Resting energy expenditure
- timeFrame
- Approximatly 4 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy. * Patients with unbalanced thyroid hormones. * Aged 18-65 years at the time of screening. * Provision of written informed consent. Exclusion Criteria: * Patients with Diabetes. * Patients with any other chronic inflammatory diseases. * Steroid treatment.
References
Publications (5)
- BACKGROUNDYen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001 Jul;81(3):1097-142. doi: 10.1152/physrev.2001.81.3.1097. PMID 11427693
- BACKGROUNDSchwartz HL, Oppenheimer JH. Physiologic and biochemical actions of thyroid hormone. Pharmacol Ther B. 1978;3(3):349-76. doi: 10.1016/s0306-039x(78)80002-6. No abstract available. PMID 203955
- BACKGROUNDBrand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005 Aug;2(2):85-93. doi: 10.1016/j.cmet.2005.06.002. PMID 16098826
- BACKGROUNDNicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984 Jan;64(1):1-64. doi: 10.1152/physrev.1984.64.1.1. No abstract available. PMID 6320232
- BACKGROUNDGjedde S, Gormsen LC, Riis AL, Jorgensen JO, Rungby J, Moller N, Weeke J, Pedersen SB. Reduced expression of uncoupling protein 2 in adipose tissue in patients with hypothyroidism. J Clin Endocrinol Metab. 2010 Jul;95(7):3537-41. doi: 10.1210/jc.2009-0907. Epub 2010 Apr 28. PMID 20427509