Clinical trial · Interventional
An Investigation of Light Therapy for Cancer-related Fatigue (The LITE Study)
A Randomized Controlled Trial of Light Therapy on Biomarkers, Sleep/Wake Activity, and Quality of Life in Individuals With Post-treatment Cancer-related Fatigue
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cancer-related fatigue is one of the most common and distressing symptoms associated with a cancer diagnosis.Fatigue related to cancer often appears before a diagnosis, worsens during treatment, and lasts for years after treatment in up to 35% of patients. Despite the long-term effects of cancer-related fatigue, the treatment options available are not always appropriate or helpful for all patients.Light therapy is an effective treatment for other disorders related to fatigue. The purpose of the study is to investigate the role of light therapy on quality of life, sleep patterns, and physical measures of immune function and stress hormones in individuals with post-treatment cancer-related fatigue.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bright white light | Device | — | UNRESOLVED |
| Dim red light | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Bright White Light
- description
- Bright white light exposure every morning for 30 minutes for 28 consecutive days
- interventionNames
- Device: Bright white light
- type
- ACTIVE_COMPARATOR
- label
- Dim Red Light
- description
- Dim red light exposure every morning for 30 minutes for 28 consecutive days
- interventionNames
- Device: Dim red light
Primary outcomes (1)
- measure
- Change in fatigue symptoms from baseline to post-treatment
- timeFrame
- Baseline, after each treatment week (each week for 4 weeks), and at week 5
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * English speaking * Non metastatic cancer * At least 3 months post chemotherapy/radiation treatment (hormone treatment ok) * Meets criteria for cancer-related fatigue Exclusion Criteria: * Under 18 years of age * Presence of a sleep disorder other than insomnia or hypersomnia * Shift work * Presence of an Axis-I psychiatric condition * Presence of a medical condition that may impact levels of fatigue * Presence of conditions contraindicated to the use of light therapy or photosensitizing medications * Randomization refusal
References
Publications (1)
- DERIVEDJohnson JA, Subnis U, Carlson LE, Garland SN, Santos-Iglesias P, Piedalue KL, Deleemans JM, Campbell TS. Effects of a light therapy intervention on diurnal salivary cortisol in fatigued cancer survivors: A secondary analysis of a randomized controlled trial. J Psychosom Res. 2020 Dec;139:110266. doi: 10.1016/j.jpsychores.2020.110266. Epub 2020 Oct 6. PMID 33070045