Clinical trial · Observational
A Study of Pancreatic Cancer in Xenografts From Liver Metastases
A Feasibility Study Of Developing Murine Primary Xenografts From Biopsies Of Liver Metastases In Patients With Advanced Pancreatic Cancer
NCT01774643CI-TRIAL-00063106completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a feasibility study to perform image-guided liver biopsies in 25 patients who have pancreatic cancer with liver metastasis (cancer in the pancreas that has spread to the liver). This will contribute with samples for the bio-bank (bank of tumors) and develop xenografts (human tumors growing in mice) for further analysis of genes.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Blood Samples | — | UNRESOLVED | — |
| Liver Metastases | — | UNRESOLVED | — |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
| Tumor Tissue Biopsy | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Pancreatic cancer with liver metastases
- description
- Tumor tissue biopsy, blood samples
Primary outcomes (4)
- measure
- Number of patients with adverse events due to biopsies
- timeFrame
- up to 2 years
- description
- Monitoring adverse events during trial related to biopsies
- measure
- Number of successful xenografts
- timeFrame
- up to 2 years
- description
- determine the "take rate" or success of establishing xenografts
- measure
- Number of similarities and differences between original patient tumor sample with xenograft sample
- timeFrame
- up to 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Minimum age of 18 years old * Pancreatic cancer with liver metastasis * No contraindication to image-guided biopsy of liver metastasis, including uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine etc) and no significant hepatic dysfunction. * Provide written informed consent * ECOG 0,1 or 2 Exclusion Criteria: * Inability to lie supine for more than 30 minutes * ECOG 3 or more * Serious medical risk factors involving any of the major organ systems or including uncontrolled bleeding diathesis, uncontrolled malignant pain, inability to lie supine etc) and no significant hepatic dysfunction.
References
Publications (0)
Data not yet available
No reference posted for this study.