Huaier Granule for Prevention of Recurrence and Metastasis of Hepatocarcinoma After Radical Hepatectomy

Inclusion Criteria:

* Age: ≥ 18 and ≤ 75 years, both male and female;
* Radical hepatectomy has been performed for hepatocellular carcinoma;
* The hepatocellular carcinoma has been confirmed by pathological examination;
* Barcelona clinic liver cancer(BCLC) stage A or B;
* Not receiving any preoperative anticancer drug;
* The liver and kidney function satisfies the following conditions within 15 days after surgery (excluding day 15): aspartate aminotransferase(AST), glutamic-oxalacetic transaminase(ALT)\<3 upper limit of normal(ULN), total bilirubin≤2ULN, serum creatinine \<1.5 ULN;
* Other laboratory tests meet the following requirements within 15 days after surgery (excluding day 15): Hb≥9g/dl, platelet count≥60×109/L, absolute neutrophil count\>1.0×109/L;
* The expected survival time ≥ 12 weeks;
* The subjects volunteer to sign the informed consent.

Exclusion Criteria:

* Hepatocellular carcinoma patients who received non-radical hepatectomy;
* Non-hepatocellular carcinoma patients;
* Those with Child-Pugh C;
* Pregnant or lactating women;
* Those with active bleeding due to various reasons;
* Those with HIV infection or AIDS-associated diseases;
* Those with severe acute and chronic diseases;
* Those with severe diabetes;
* Those with serious infectious diseases;
* Those who can not take drugs by oral route;
* Drug abusers or those with psychological or mental diseases that may interfere with study compliance;
* Conditions that are considered not suitable for this study investigators