Clinical trial · Interventional
ESTD vs. VATS for Upper Gastrointestinal Submucosal Tumors
Endoscopic Submucosal Tunnel Dissection Versus Video-assisted Thoracoscopic Surgery for Upper Gastrointestinal Submucosal Tumors: a Prospective Randomized Controlled Trial
NCT01768104CI-TRIAL-00008907unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the efficacy and safety of endoscopic submucosal tunnel dissection (ESTD) compared with video-assisted thoracoscopic surgery (VATS) in the treatment of upper gastrointestinal submucosal tumors.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Stromal Tumors (GISTs) | Gastrointestinal Stromal Tumor | ONTOLOGY_EXACT | 0.85 |
| Leiomyoma | Leiomyoma | ONTOLOGY_EXACT | 0.98 |
| Upper Gastrointestinal Submucosal Tumors (SMTs) | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ESTD | Procedure | — | UNRESOLVED |
| VATS | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- ESTD
- description
- Endoscopic submucosal tunnel dissection (ESTD) for patients with upper gastrointestinal submucosal tumors (SMTs)
- interventionNames
- Procedure: ESTD
- type
- ACTIVE_COMPARATOR
- label
- VATS
- description
- Video-assisted thoracoscopic surgery (VATS) for patients with upper gastrointestinal submucosal tumors (SMTs)
- interventionNames
- Procedure: VATS
Primary outcomes (1)
- measure
- En bloc resection
- timeFrame
- During the operation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Between 18 and 75 years of age * Patient with upper gastrointestinal submucosal tumor * Signed informed consent Exclusion Criteria: * Severe cardio-pulmonary disease or other serious disease leading to unacceptable surgical risk * Endoscopic ultrasound (EUS) or CT signs of metastasis * Mega-oesophagus (greater than 7 cm) or Oesophageal diverticula in the distal oesophagus * Previous oesophageal or gastric surgery * Pregnancy or lactation women, or ready to pregnant women * Not capable of filling out questionnaires
References
Publications (2)
- BACKGROUNDGong W, Xiong Y, Zhi F, Liu S, Wang A, Jiang B. Preliminary experience of endoscopic submucosal tunnel dissection for upper gastrointestinal submucosal tumors. Endoscopy. 2012 Mar;44(3):231-5. doi: 10.1055/s-0031-1291720. Epub 2012 Feb 21. PMID 22354823
- BACKGROUNDZhao Y, Cai K, Liu D, Wu H, Xiong G, Wang H, Huang Z, Cai R, Wu X. [Video-assisted thoracoscopic removal of esophageal leiomyomas with intraoperative tumor location by endoscopy]. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Apr;32(4):586-8. Chinese. PMID 22543150