Clinical trial · Interventional
A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
NCT01758666CI-TRIAL-00020267unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
At present, the most effective drugs to osteosarcoma include ADM,DDP,,HD-MTX,IFO and so on.The effective rate of single drug was about 30%, and if the chemotherapy contains HD-MTX, the survival rate can reach about 60%, so the HD-MTX is the most important component in patients of osteosarcoma. Studies have shown that, MTX efficacy and adverse reactions were associated with blood concentration level and duration, selecting the right time and dose to give CF is the critical point.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Osteosarcoma | Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Methotrexate,Calcium folinate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Methotrexate and Calcium folinate
- interventionNames
- Drug: Methotrexate,Calcium folinate
Primary outcomes (1)
- measure
- blood concentration of MTX
- timeFrame
- up to 3 years
Secondary outcomes (1)
- measure
- other adverse reaction
- timeFrame
- up to 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: 1. Proved by pathology in 60 cases of osteosarcoma patients 2. PS ≤ 2, survival period is more than 6 months 3. Normal function of liver and kidney 4. No chemotherapy contraindication, patients treat with high dose methotrexate 5. Get signed written informed consent form 6. Have a good compliance with take blood and follow-up Exclusion Criteria:
References
Publications (0)
Data not yet available
No reference posted for this study.