Clinical trial · Observational
Predicting Tolerance to Radiation Therapy in Older Adults With Cancer
Predicting Tolerance to Radiation Therapy in Older Adults With Cancer: A Prospective Blinded Study of the Comprehensive Geriatric Assessment
NCT01752751CI-TRIAL-00033166completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A comprehensive geriatric assessment tool developed by Hurria and colleagues has been used in non-radiation oncology clinical settings to predict how older adults tolerate cancer treatments. The investigators think this same tool (referred to as the CGA) can be used in a radiation oncology clinic to predict for poor treatment tolerance.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pre-treatment Loss of Independent Activities of Daily Living | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Cancer Patients Age 65 or above
- description
- Cancer patients age 65 years or above with a diagnosis of head and neck cancer or lung cancer with radiotherapy or chemoradiotherapy planned as part of curative standard treatment.
Primary outcomes (1)
- measure
- Association between pre-treatment loss of at least one independent activity of daily living (I-ADL) and poor tolerance to radiation therapy
- timeFrame
- 4-8 weeks post-radiation therapy
- description
- To assess the association between pre-treatment loss of at least one independent activity of daily living (I-ADL) on the CGA and poor tolerance to radiation therapy
Secondary outcomes (5)
- measure
- Association between pre-treatment loss of at least one independent activity of daily living (I-ADL) and the occurrence of any patient-reported toxicity from radiation therapy
- timeFrame
- 4-8 weeks post-radiation therapy
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ≥Age 65 years (no upper age limit) * Diagnosis of either head and neck cancer, or lung cancer with either radiotherapy or chemoradiotherapy planned as part of standard treatment. * Consented for receipt of External Beam Radiation Therapy (EBRT) at UNC Chapel Hill * Able to read English (required for CGA) * Curative treatment intent as defined by their radiation oncologist Signed, IRB-approved written informed consent * Patients enrolled in other CGA studies will not be excluded (see LCCC 0916, 1208) Exclusion Criteria: * ≥Age 65 years (no upper age limit) * Diagnosis of either head and neck cancer, or lung cancer with either radiotherapy or chemoradiotherapy planned as part of standard treatment. * Consented for receipt of EBRT at UNC Chapel Hill * Able to read English (required for CGA) * Curative treatment intent as defined by their radiation oncologist Signed, IRB-approved written informed consent * Patients enrolled in other CGA studies will not be excluded (see LCCC 0916, 1208)
References
Publications (1)
- BACKGROUNDVanderWalde NA, Deal AM, Comitz E, Stravers L, Muss H, Reeve BB, Basch E, Tepper J, Chera B. Geriatric Assessment as a Predictor of Tolerance, Quality of Life, and Outcomes in Older Patients With Head and Neck Cancers and Lung Cancers Receiving Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017 Jul 15;98(4):850-857. doi: 10.1016/j.ijrobp.2016.11.048. Epub 2016 Dec 2. PMID 28258889