Clinical trial · Observational
Effects of Chemotherapy on Muscle Mass and Exercise Performance in Patients With Oesophageal Cancer.
Effect of Neoadjuvant Chemotherapy on Muscle Mass and Peri-operative Cardiorespiratory Performance in Patients Undergoing Oesophageal Cancer- a Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oesophageal Adenocarcinoma | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| cardio-pulmonary exercise testing (CPEX) | Other | — | UNRESOLVED |
| DEXA scan | Radiation | — | UNRESOLVED |
| Muscle biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- oesophageal adenocarcinoma
- description
- DEXA scan cardio-pulmonary exercise testing (CPEX) muscle biopsy
- interventionNames
- Radiation: DEXA scan
- Procedure: Muscle biopsy
- Other: cardio-pulmonary exercise testing (CPEX)
Primary outcomes (1)
- measure
- muscle mass
- timeFrame
- 3 months
- description
- variations in muscle mass during neoadjuvant chemotherapy
Secondary outcomes (4)
- measure
- nutritional status
- timeFrame
- 3 months
- description
- assess nutritional status post chemotherapy via serum protein levels.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * oesophageal cancer * Multidisciplinary team decision to offer neoadjuvant chemotherapy prior to surgery Exclusion Criteria: * Metastatic disease
References
Publications (0)
Data not yet available