Application of the Stem Cell Therapy in the End Stage Liver Disease and Assessment Its Consequences in the Quality of Live Style as Well as Development of HCC.

Inclusion Criteria:

* Male or female patients aged from 20 to 65 years of age.
* Evidence of chronic liver insufficiency.
* The presence of decreased serum albumin and/or increased bilirubin and/or increased international normalized ratio (INR).
* Patient is unlikely to receive a liver transplant.
* Ability to give written consent
* Women of childbearing potential may be included, but must use a reliable and appropriate contraceptive method

Exclusion Criteria:

* Patients below the age of 20 or above the age of 65 years
* Pregnant or lactating women
* Patients with recent recurrent GI bleeding or spontaneous bacterial peritonitis
* Patients with evidence of HIV or other life threatening infection
* Patients unable to give informed consent
* Patients with a history of hypersensitivity to G-CSF
* Patients who have been included in any other clinical trial within the previous month
* Patient with recurrent attacks of hepatic encephalopathy.
* Evedince of portal vein thrombosis by ultrasound.