Single Fraction Elderly Breast Irradiation (SiFEBI)

Irradiation and Accelerated Partial Breast (IPAS) to this day remains a therapeutic concept whose validity is being assessed on its non-inferiority in terms of local control compared to whole breast irradiation. At least eight phase III trials attempting to answer this question and thus provide a sufficient level of evidence to make this concept a new standard of care for sub-groups of patients well defined (1). However, without waiting for the final results of these randomized trials (which will not be fully valid with a drop of at least ten years), the American societies (ASTRO) and European (ESTRO) radiotherapy have all two proposed classification (very similar) into 3 groups according to the risk to the patient in terms of local recurrence after IPAS. And are defined by the ESTRO: * The low-risk group ("suitable" for ASTRO) * The intermediate-risk group ("cautionary" in ASTRO) * The high-risk group ("not suitable" for ASTRO) (2.3). Therefore, it is possible to propose to a patient a randomized clinical tria IPAS, to subject it belongs to the group "low risk." The results of phase II trials as a long-term analysis of the matched team of William Beaumont Hospital (4) and the phase III trial using intra-operative radiation photons in low energy X whose results were recently published (5) confirm the value of this new therapeutic concept for post-operative breast cancer at low risk of local recurrence. In France, the therapists were quickly directed to a sub-population for which the IPAS could represent a real improvement in the therapeutic management in significantly reducing the number of irradiation sessions of thirty in 6 weeks 5 days at 10 in a single view (6). Several French phase II trials were started specifically targeting the female population aged using a balloon catheter (MammoSite ®) (7) or by intra-operative radiation électronthérapie (8). The results of the test using the GERICO-03 brachytherapy with high dose rate (promoter: FNCLCC, National Federation of Anti Cancer Centres , recently merged into Group Health Cooperation entitled UNICANCER) are currently submitted to Journal Green Radiotherapy (Radiotherapy and Oncology from 09/11/11) (9). On a technical level, two main approaches are used (10): * Irradiation intraoperative electron or low-energy photons, * Radiation after surgery The advantage of intraoperative irradiation is the optimal reduction of total processing time radio-surgery because the patient is irradiated during the lumpectomy. However, 15-20% of these patients receive partial breast irradiation, as histo-prognostic criteria provided in the histologically final report, confirm the non-adapted indication of IPAS (5). In contrast, the post-operative IPAS can treat only patients meeting all criteria for IPAS but treatment-related travel are about 5 treatments for bi-fractionated (2 sessions per days separated by at least 6 hours).

Sex

Female

Minimum age

70 Years

Inclusion Criteria:

* Patient WITHinvasive breast cancer histologically proved: ductal, lobular, medullary, papillary, tubular or colloid:

  * All grades histo-prognostic
  * pT1 tumor size (\<20 mm),
  * healthy Margins surgical
  * unifocal lesion
  * Any hormone receptor,
  * Any Her2 status,
  * No lymph node (sentinel lymphadenectomy or) or micrometastases (pN0, pN1mic)
* Age greater than or equal to 70 years
* Score Balducci I or II,
* Karnofsky index greater than or equal to 70%
* Time between lumpectomy and radiation less than 2 weeks
* Implementation of clips in the tumor bed intraoperatively,
* Patient having taken note of the information note and who signed the informed consent
* Patient receiving social security coverage.

Exclusion Criteria:

* Lobular carcinoma in situ or pure ductal carcinoma in situ or non-epithelial tumor type sarcoma or lymphoma,
* Component extensive ductal in situ associated
* Peritumoral lymphatic emboli,
* Distance Metastasis
* Inflammatory Breast Cancer,
* Multifocal tumor (covering a total distance inter-end of 40 mm or more)
* Previous treatment for this tumor including breast radiotherapy and / or chemotherapy neoadjuvant or adjuvant
* History of plastic surgery breast
* Unknown or safety margins positive for invasive carcinoma
* Absence of clips in the tumor bed,
* Time between lumpectomy and radiation greater than or equal to 2 weeks
* Active infection or other serious comorbidity that could prevent the patient receiving the treatment,
* History of cancer other than a basal cell skin or carcinoma in situ of the cervix or other cancer in complete remission for more than 5 years
* Psychiatric illness

• DERIVEDHannoun-Levi JM, Cham Kee DL, Gal J, Schiappa R, Hannoun A, Gautier M, Boulahssass R, Peyrottes I, Barranger E, Ferrero JM, Chand ME, Doyen J. Accelerated partial breast irradiation for suitable elderly women using a single fraction of multicatheter interstitial high-dose-rate brachytherapy: Early results of the Single-Fraction Elderly Breast Irradiation (SiFEBI) Phase I/II trial. Brachytherapy. 2018 Mar-Apr;17(2):407-414. doi: 10.1016/j.brachy.2017.11.008. Epub 2017 Dec 15. PMID 29254856