Clinical trial · Observational
Modeling Study to Predict Progression of Anal Cancer Pre-cursor Lesions in HIV
Predictive Modeling of Anal Dysplasia Progression in HIV
NCT01709448CI-TRIAL-00008294unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether a model can be created to predict the progression of early anal cancer precursor lesions in HIV using potential predictors such as: HIV treatment history, smoking history, sexual history, human papillomavirus viral load, human papillomavirus protein expression, and cell markers associated with progression of HPV-related lesions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neoplasms, Squamous Cell | Squamous Cell Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Papillomavirus Infections | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- histological diagnosis of high-grade squamous intra-epithelial lesion confirmed by anal biopsy
- timeFrame
- 12 months, 24 months, 36 months
Secondary outcomes (1)
- measure
- Regression of lesions defined by normal appearance on anoscopy and normal histology on anal biopsy following previous diagnosis of squamous intraepithelial lesion.
- timeFrame
- 12 months, 24 months, 36 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * HIV-infected * Age \> 18 years old * Abnormal anal screening cytology Exclusion Criteria: * Inability to sign informed consent * Life-threatening illness or other contraindication for high-resolution anoscopy * anal intraepithelial neoplasia not confirmed by anal biopsy * history of anal carcinoma * history of HPV vaccination
References
Publications (0)
Data not yet available
No reference posted for this study.