Clinical trial · Observational
Neurofibromatosis Type 1 Brain Tumor Genetic Risk
Genetic Variation and Risk of Pediatric Brain Cancers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will analyze DNA samples to determine associations between maternal and offspring genetic factors and pediatric brain tumor development in children with Neurofibromatosis Type 1. Participating families (mother, father, child) will be asked to complete a short questionnaire and provide DNA samples (either saliva or blood). The information gained from your participation may one day help doctors develop strategies to reduce brain tumor risk in individuals with NF1. Please note: there is no therapy associated with this study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Neurofibromatosis Type 1 | — | UNRESOLVED | — |
| Pediatric Brain Tumor | Childhood Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Family
- description
- Families with a child with Neurofibromatosis Type 1 who has been diagnosed with a brain tumor.
Primary outcomes (1)
- measure
- Brain Tumor
- timeFrame
- September 1, 2012-February 1, 2014
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Pediatric participant (born during 1994-2012) with NF1 and diagnosed with a brain tumor * Biological mother or father (or full sibling if mother or father is unable to participate) able to participate * All family members (pediatric participant, biological mother, and biological father or full sibling) must be willing to contribute a blood or saliva sample * ability to understand consent forms Exclusion Criteria: -those who do not meet inclusion criteria
References
Publications (0)
Data not yet available