Clinical trial · Interventional
Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker
Different Strategies Using Autoantibodies and/or CT Scan Detection of Lung Cancer
NCT01700257CI-TRIAL-00049213completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lung cancer is the number one cancer killer in the USA. Early stage lung cancer is asymptomatic. Most patients with lung cancer are usually symptomatic at diagnosis and already have advanced stage disease. Low dose CT screening (LDCT) for high risk individuals has recently been shown to decrease lung cancer mortality by 20%. However, 4 out of 5 lung cancer deaths are not prevented with LDCT screening alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| High Risk of Developing Lung Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CT scan & Early CDT Lung test | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- CT scan & Early CDT Lung test
- description
- Every study participant receives a CT scan \& Early CDT-Lung test (biomarker blood test) for lung cancer screening purposes.
- interventionNames
- Radiation: CT scan & Early CDT Lung test
- Other: CT scan & Early CDT Lung test
Primary outcomes (1)
- measure
- CT alone vs. both Early CDT-Lung test and CT scan.
- timeFrame
- One year
- description
- Assess the number of lung cancers detected with CT alone vs. with both Early CDT-Lung test and CT scan. Compare positive CT results with positive/negative Early CDT Lung test results and assess ability of the combination to detect earlier stage lung cancer.
Secondary outcomes (1)
- measure
- Value of Early CDT-lung test in detecting cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Smokers or former smokers * At least 20 pack year history of smoking * Ages 50 - 75 Exclusion Criteria: * Had a CT scan of chest within last 24 months * History of any cancer within 10 yrs (except skin cancer or cervical cancer) * A serious illness that decreases life expectancy to less than 5 years * Any current use of Oxygen * Uncontrolled congestive heart failure or cardiac arrhythmia that would prevent surgery for a lung lesion * Severe COPD or dyspnea that would prevent lung surgery or stereotactic body radiotherapy
References
Publications (0)
Data not yet available
No reference posted for this study.