Clinical trial · Interventional
Endoscopic Detection of Dysplasia in Barrett's Esophagus
High Resolution Magnifying Endoscopy and Contrast Enhanced Imaging Versus Standard White Light Endoscopy for the Detection of Dysplasia in Barrett's Esophagus. A Prospective Blinded Cross-over Study.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether High Resolution Magnification Endoscopy (HRME) and Computed Virtual Chromoendoscopy (CVC) with targeted biopsies is superior to conventional white light endoscopy (WLE) with 4 quadrant biopsies of the metaplastic epithelium every 1-2 cm (Seattle Protocol) for detection of pre-malignant lesions in patients with Barrett's Esophagus (BE).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett's Esophagus | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| conventional endoscopy | Procedure | — | UNRESOLVED |
| HRME+CVC | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Introductory conventional endoscopy
- description
- Conventional endoscopy followed by HRME+CVC after 30 days.
- interventionNames
- Procedure: HRME+CVC
- type
- ACTIVE_COMPARATOR
- label
- Introductory HRME+CVC
- description
- HRME+CVC followed by conventional endoscopy after 30 days.
- interventionNames
- Procedure: conventional endoscopy
Primary outcomes (1)
- measure
- Incidence of detected dysplasia by each endoscopic technique.
- timeFrame
- Up to 36 months.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Presence of specialized intestinal metaplasia in biopsies from the esophagus Exclusion Criteria: * Dysplasia or cancer
References
Publications (1)
- DERIVEDBratlie SO, Johnsson E, Jonsson C, Fandriks L, Edebo A. Multiple-Band Imaging Provides Better Value Than White-light Endoscopy in Detection of Dysplasia in Patients With Barrett's Esophagus. Clin Gastroenterol Hepatol. 2015 Jun;13(6):1068-74.e2. doi: 10.1016/j.cgh.2014.12.007. Epub 2014 Dec 11. PMID 25499989