Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans

Inclusion Criteria:

* Between ages of 21-70 years old.
* Body mass index of between 18 and 27 kg/m2 (inclusive).
* Eastern Cooperative Oncology Group (ECOG)performance status of O.
* Not currently be taking carotenoid supplements
* Have Blood Urea Nitrogen (BUN)/Creatinine (CR), liver enzymes, Complete Blood Count (CBC), and Prothrombin time (PT/PTT/INR) within normal limits.
* Have a hemoglobin level of at least 11 g /dL at the time of randomization.
* Voluntarily agree to participate and sign an informed consent document.

Exclusion Criteria:

* Have a known allergy or intolerance to tomatoes.
* Have a history of a nutrient malabsorption disease (such as celiac disease) or other metabolic disorders requiring special diet recommendations.
* Have uncontrolled hyperlipidemia (total cholesterol \> 200 mg/dL, LDL \> 160 mg/dL and serum triglycerides \> 200 mg/dL) or lipidemia that may influence carotenoid pharmacokinetics or transport.
* Smoke tobacco products
* Have a history of pituitary hormone diseases that currently require supplemental hormonal administration (thyroid hormones, ACTH, growth hormone) or other endocrine disorders requiring hormone administration with the exception of diabetes and osteoporosis.
* Are taking certain medications (prescription or over-the-counter) such as Orlistat, which interfere with dietary fat absorption.
* Are taking complementary and alternative medications that at the discretion of the study physician Steven K. Clinton(SKC) may interfere with carotenoid absorption or metabolism.