Clinical trial · Interventional
Comparison of the Effects of Vecuronium and Cisatracurium on Electrophysiologic Monitoring During Neurosurgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recently intraoperative motor evoked potential monitoring (MEP) is widely used to reduce neural damage during neurosurgery. As neuromuscular blockade(NMB) during MEP monitoring decreases the amplitude of MEP, partial NMB is usually maintained during general anesthesia. Continuous infusion of NMB agent is preferred than bolus infusion during MEP monitoring. There are a lot of NMB agents in clinical use. But there have been no reports about the effect of changing NMB agent on efficacy of MEP monitoring. Therefore, the investigators performed a randomized controlled trial to evaluate the effect of changing NMB agent on the variability of MEP amplitude during neurosurgery.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Cerebral Aneurysm | — | UNRESOLVED | — |
| General Anesthesia | — | UNRESOLVED | — |
| Motor Evoked Potential Monitoring | — | UNRESOLVED | — |
| Neurosurgery | — | UNRESOLVED | — |
| Spine Tumor | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MEP monitoring with continuous infusion of cisatracurium during general anesthesia | Other | — | UNRESOLVED |
| MEP monitoring with continuous infusion of vecuronium during general anesthesia | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cisatracurium Group
- description
- MEP monitoring with continuous infusion of cisatracurium during general anesthesia
- interventionNames
- Other: MEP monitoring with continuous infusion of cisatracurium during general anesthesia
- type
- ACTIVE_COMPARATOR
- label
- Vecuronium Group
- description
- MEP monitoring with continuous infusion of vecuronium during general anesthesia
- interventionNames
- Other: MEP monitoring with continuous infusion of vecuronium during general anesthesia
Primary outcomes (20)
- measure
- MEP amplitude
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients undergoing neurosurgery with intraoperative motor evoked potential monitoring Exclusion Criteria: * Patients who can not undergo motor evoked potential monitoring due to central or peripheral neuromuscular disease (e.g. Cerebral palsy, Myasthenia gravis, Acute spinal injury, neurologic shock) * Patients with hepatic or renal disease with altered metabolism of vecuronium * Patients with medication which influence the metabolism of vecuronium (e.g. calcium channel blocker, aminoglycoside antibiotics, Lithium, MgSO4)
References
Publications (0)
Data not yet available