Clinical trial · Interventional
Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Interest of Morphometric Analysis of Sputum Cytology for Lung Cancer Screening in Workers Highly Exposed to Asbestos - Exploratory Analysis of Biomarkers Predictive for Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan. An ancillary study will evaluate the interest of blood predictive biomarkers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| low-dose CT-scan AND induced sputum sample AND blood test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Screening
- description
- Paired-design: low-dose CT scan, sputum sample and blood test will be performed on all subjects.
- interventionNames
- Other: low-dose CT-scan AND induced sputum sample AND blood test
Primary outcomes (2)
- measure
- Risk of false positive
- timeFrame
- within 3 months
- description
- Ratio of false positives (RFP) for detection of lung cancer in reference to conventional cytology analysis of sputum
- measure
- detection of lung cancer
- timeFrame
- within 3 months
- description
- Ratio of sensitivities for detection of lung cancer in reference to conventionnal cytology analysis of sputum
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 56 Years
Show eligibility criteria text
Inclusion Criteria: * High professional asbestos exposure * Member of a former cohort recruited between 2000 and 2006 in Caen, Rouen and Le Havre (inclusion criteria: 50-75 years at the time of initial recruitment, high intermittent asbestos exposure \>= 1 year, or high discontinuous asbestos exposure \>=10 years). All the living members of the cohort will be contacted: a maximum of 1000 subjects is expected, probably less. * Informed consent signed Exclusion Criteria: * Personal history of lung cancer * Refusal of the study protocol * Uncontrolled asthma or lung failure
References
Publications (0)
Data not yet available