Clinical trial · Interventional
Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage
Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage in Advanced Biliary Tract Malignancy That Failed ERCP (PETRUS Study): A Randomized Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with obstructive jaundice due to locally advanced/metastatic malignancy with dilated intrahepatic bile ducts will be recruited from the department of Gastroenterology and Hepatology at the University Hospital of Leuven. This population will have failed ERCP or will be considered when ERCP is not possible due to altered surgical anatomy. Patients will be randomized to either PTC or EUS guided biliary drainage
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Biliary Obstruction | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Percutaneous transhepatic cholangiography vs. endoscopic biliary drainage | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Percutaneous Transhepatic cholangiography
- interventionNames
- Procedure: Percutaneous transhepatic cholangiography vs. endoscopic biliary drainage
- type
- ACTIVE_COMPARATOR
- label
- Endoscopic Ultrasound guided biliary drainage
- interventionNames
- Procedure: Percutaneous transhepatic cholangiography vs. endoscopic biliary drainage
Primary outcomes (1)
- measure
- Pain: Post-procedural pain as measured by visual analogue score (VAS) at 2, 24, and 72 hours following the procedures
- timeFrame
- 72 hours
- description
- \- Primary endpoints * Pain: Post-procedural pain as measured by visual analogue score (VAS) at 2, 24, and 72 hours following the procedures * Biochemical changes: Bilirubin decrease at 2 and 4 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients older than 18 years presenting with malignant obstructive jaundice * Locally advanced primary or metastatic malignancy involving the biliary tract * Patients in whom an ERCP have failed or where an ERCP is not possible due to surgically altered anatomy (eg. Post-Whipple). Exclusion Criteria: * Resectable biliary tract malignancy with curative intent
References
Publications (0)
Data not yet available