Clinical trial · Interventional
Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome
Letrozole Versus Clomiphene Citrate Plus Metformin in the First Treatment of Infertility in Patients With Polycystic Ovarian Syndrome
NCT01679574CI-TRIAL-00007964PCOcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and Clomiphene in infertile women with polycystic ovary syndrome (PCOS) not treated before with any ovulation induction agent
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (3)
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- letrozole
- description
- Letrozole tablets (Femara; Novartis Pharma, Switzerland) 2.5 mg letrozole daily from day 3 of the menses for 5 days
- interventionNames
- Drug: Letrozole
- type
- ACTIVE_COMPARATOR
- label
- Metformin and clomiphene
- description
- .Drug: metformin (Cidophage®; CID,Cairo, Egypt) metformin 1500 daily for 3 months * Drug: CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt) 100 mg CC for 5 days starting from day 3 of menstruation
- interventionNames
- Drug: Clomiphene
- Drug: Metformin
Primary outcomes (1)
- measure
- ovulation rate
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * All participants met the Rotterdam consensus criteria for the diagnosis of PCOS . .Primary infertility because of anovulation for at least 1 year. * Only fresh (not treated previously) cases were recruited. .The male partner of each participant was required to have a normal result on semen analysis (count\>20million/ml,motility\>40%and normal morphology \>30%). * Each woman was required to have patent tubes on hysterosalpingography or on a diagnostic laparoscopy. Exclusion Criteria: * Age below 18 years or above 35 years , trial of ovulation induction prior to the stud ,BMI \>35 . * Presence of other causes of infertility; hyperprolactinemia (morning plasma prolactin concentration 30 ng/mL or more); any other endocrine, hepatic, or renal disorder; presence of an organic pelvic mass; * History of abdominal surgery that might have caused pelvic factor infertility.
References
Publications (0)
Data not yet available
No reference posted for this study.