Clinical trial · Interventional
Gastric Cancer Prevention in the Family Members by Helicobacter Pylori Eradication
Helicobacter Pylori Eradication to Prevent Gastric Cancer in Subjects With Family History of Gastric Cancer: A Randomized Controlled Study
NCT01678027CI-TRIAL-00071232active not recruitingPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluate whether treatment of Helicobacter pylori infection reduces the incidence of gastric cancer in subjects with family history of gastric cancer.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Family Members | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Helicobacter Pylori Infection | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| LAC triple therapy | Drug | — | UNRESOLVED |
| Placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Placebo for LAC triple therapy
- interventionNames
- Drug: Placebo
- type
- ACTIVE_COMPARATOR
- label
- LAC triple therapy
- description
- PPI (Lansoprazole), Clarithromycin, Amoxicilline
- interventionNames
- Drug: LAC triple therapy
Primary outcomes (1)
- measure
- Gastric cancer incidence
- timeFrame
- 6 years after last participant enrollment
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Sibling or offspring of patients with gastric adenocarcinoma confirmed by EGD and biopsy * Informed consent should be signed Exclusion Criteria: * Gastric cancer history * Other malignancy within the past 5 years * Hereditary cancer family member (HNPCC, FAP) * Peptic ulcer history * Peptic ulcer, esophageal cancer, gastric cancer case found at EGD * H. pylori eradication treatment history * Previous serious side effect to antibiotics * Serious concurrent infection or nonmalignant disease such as liver cirrhosis, renal failure, cardiovascular diseases * Pregnant or nursing women * Psychiatric disorder that would preclude compliance, alcoholics * Refuse informed consent
References
Publications (1)
- DERIVEDChoi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, Joo J. Family History of Gastric Cancer and Helicobacter pylori Treatment. N Engl J Med. 2020 Jan 30;382(5):427-436. doi: 10.1056/NEJMoa1909666. PMID 31995688